Age at onset and latency to treatment (duration of untreated illness) in patients with mood and anxiety disorders: a naturalistic study
Age at onset and latency to treatment (duration of untreated illness) in patients with mood and anxiety disorders: a naturalistic study
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DOI：
10.1097/yic.0b013e3283384c74
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发表时间：
2010-05-01
影响因子：
2.6
通讯作者：
Dell'Osso, Bernardo
中科院分区：
文献类型：
--
作者：
Altamura, Alfredo Carlo;Buoli, Massimiliano;Dell'Osso, Bernardo
本研究旨在调查和比较不同情绪和焦虑障碍患者的人口学和临床特征，特别强调发病年龄、首次治疗年龄，特别是未治疗疾病的持续时间（DUI）。研究样本包括729例门诊患者，诊断为重度抑郁症（181例）、双相情感障碍I型（115例）和II型（186例）、广泛性焦虑障碍（100例）、惊恐障碍（96例）和强迫症（51例）。采用单因素方差分析或chi(2)检验比较诊断组间样本的主要人口学和临床变量。诊断组在发病年龄和首次药物治疗年龄以及治疗潜伏期方面表现出显著差异。其中重度抑郁症患者DUI最短（39.08个月），重度双相障碍患者DUI最长（97.2个月）。在焦虑障碍组（F = 7.512, P < 0.001）中，惊恐障碍组DUI最短（44.35个月），强迫症组最长（90.57个月）。本研究结果表明，不同心境和焦虑障碍患者在发病年龄、首次治疗年龄以及由此导致的DUI方面存在显著差异，这可能反映了影响治疗延迟的不同原因。国际临床精神药物杂志25:172-179 (c) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins。
This study was designed to investigate and compare demographic and clinical features with specific emphasis on age at onset, age at first treatment and, in particular, on duration of untreated illness (DUI), in patients with different mood and anxiety disorders. Study sample included 729 outpatients with the following diagnoses: major depressive disorder (n = 181), bipolar disorder type I (BD I, n = 115) and II (BD II, n = 186), generalized anxiety disorder (n = 100), panic disorder (n = 96), and obsessive-compulsive disorder (n = 51). Main demographic and clinical variables of the sample were compared among the diagnostic groups using one-way analysis of variance or chi(2) tests. The diagnostic groups showed significant differences in relation to age at onset and age at first pharmacological treatment and in relation to latency to treatment. In particular, patients with major depressive disorder showed the shortest DUI (39.08 months), whereas patient with BD II showed the longest DUI (97.2 months) in comparison with the other groups. Within the group with anxiety disorders (F = 7.512, P < 0.001), patients with panic disorder showed the shortest DUI (44.35 months), whereas patients with obsessive-compulsive disorder showed the longest DUI (90.57 months). The present findings suggest that patients with different mood and anxiety disorders show significant differences in terms of age at onset, age at first treatment and, consequently, DUI, which potentially reflect different reasons influencing treatment delay. Int Clin Psychopharmacol 25: 172-179 (c) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.