IL-17 and Th17 cells in human inflammatory diseases
IL-17 and Th17 cells in human inflammatory diseases
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DOI：
10.1016/j.micinf.2009.04.003
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发表时间：
2009-04-01
影响因子：
5.8
通讯作者：
Miossec, Pierre
中科院分区：
文献类型：
--
作者：
Miossec, Pierre
IL-17在1995/96年被发现为T细胞衍生的细胞因子，对炎症和中性粒细胞激活作用。在2006年，在小鼠中鉴定出IL-17的精确细胞来源，这些细胞被命名为Th17细胞。它们在与炎症和破坏有关的各种人类疾病中发挥作用，例如类风湿关节炎，牛皮癣，克罗恩病，多发性硬化症，其中IL-17被视为治疗靶点。 （c）2009 Elsevier Masson SAS。所有的战斗都保留。
IL-17 was discovered in 1995/96 as a T cell derived cytokine with effects on inflammation and neutrophil activation. In 2006, the precise cell source of IL-17 was identified in the mouse, and these cells were named Th17 cells. They play a role in various human diseases associated with inflammation and destruction such as rheumatoid arthritis, psoriasis, Crohn's disease, multiple sclerosis, where IL-17 can be seen as a therapeutic target. (C) 2009 Elsevier Masson SAS. All fights reserved.