Fusion-competent vaccines broad neutralization of primary isolates of HIV (Retracted article. See vol 296, pg 1025, 2002)
Fusion-competent vaccines broad neutralization of primary isolates of HIV (Retracted article. See vol 296, pg 1025, 2002)
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DOI：
10.1126/science.283.5400.357
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发表时间：
1999-01-15
期刊：
影响因子：
56.9
通讯作者：
Nunberg, JH
中科院分区：
文献类型：
--
作者：
LaCasse, RA;Follis, KE;Nunberg, JH
目前的重组人免疫缺陷病毒（HIV）gp 120蛋白候选疫苗不能引发能够中和患者原发分离株感染性的抗体。在这里，“融合能力”的HIV疫苗免疫原的产生，捕捉HIV结合和融合过程中出现的瞬时CD 4-辅助受体结构。在转基因小鼠免疫模型中，这些甲醛固定的全细胞疫苗引发的抗体能够中和来自不同地理位置和遗传进化枝A至E的24种主要HIV分离株中的23种的感染性。这些融合依赖性免疫原的开发可能导致广泛有效的HIV疫苗。
Current recombinant human immunodeficiency virus (HIV) gp120 protein vaccine candidates are unable to elicit antibodies capable of neutralizing infectivity of primary isolates from patients. Here, "fusion-competent" HIV vaccine immunogens were generated that capture the transient envelope-CD4-coreceptor structures that arise during HIV binding and fusion. In a transgenic mouse immunization model, these formaldehyde-fixed whole-cell vaccines elicited antibodies capable of neutralizing infectivity of 23 of 24 primary HIV isolates from diverse geographic locations and genetic clades A to E, Development of these fusion-dependent immunogens may Lead to a broadly effective HIV vaccine.