Acute hyperlipidemia increases oxidative stress more in African Americans than in white Americans
Acute hyperlipidemia increases oxidative stress more in African Americans than in white Americans
复制标题
DOI：
10.1016/s0895-7061(03)00041-4
复制
发表时间：
2003-05-01
影响因子：
3.2
通讯作者：
Egan, BM
中科院分区：
文献类型：
--
作者：
Lopes, HF;Morrow, JD;Egan, BM
氧化应激是高血压发病机制中的一个潜在因素，也是各种危险因素介导心血管和肾脏疾病的共同信号转导机制。与白人相比，更高水平的氧化应激可能会导致非裔美国人高血压及相关的心血管和肾脏并发症的发生率更高。这项研究的目的是比较两组中急性高脂血症标准化发作所引起的氧化应激。15名非裔美国人(37±1岁，9名女性/6名男性，体重指数30±2 kg/m(2))和15名白人(38±2岁，9名女性/6名男性，体重指数27±1 kg/m(2))被评估。用Intralipid和肝素持续输注4h诱导大鼠急性高脂血症。分别在基础状态、急性高脂血症后2小时和4小时采集血样，检测非酯化脂肪酸、甘油三酯和氧化应激生物标志物F2-异前列腺素。在注射Intralipid和肝素2和4小时后，非裔美国人和白人的血浆非酯化脂肪酸和甘油三酯显著增加，类似的情况也是如此。尽管基础血浆F2-Isoprostanes在不同组间没有差异，但在急性高脂血症2 h(12.2+/-2.6 v5.0+/-2.9 pg/mL，P<；0.05)和4 h(13.9+/-3.1 v3.0+/-3.0 pg/mL，P<；0.05)，非裔美国人的F2-Isoprostanes比白人增加得更多。结果表明，急性高脂血症在非裔美国人中比在白人中增加更多的F2-异前列腺素。这一发现可能对高血压、心血管和肾脏疾病患病率的种族差异具有重要意义。(C)2003年《美国高血压杂志》。
Oxidative stress emerges as a potential factor in the pathogenesis of hypertension and a common signal transduction mechanism by which various risk factors mediate cardiovascular and renal disease. A greater level of oxidative stress could contribute to higher rates of hypertension and related cardiovascular and renal complications in African Americans than in white Americans. The objective of this study was to compare oxidative stress induced by a standardized episode of acute hyperlipidemia in the two groups. Fifteen African Americans (37 +/- 1 years, 9 women/6 men, body mass index 30 +/- 2 kg/m(2)) and 15 whites (38 +/- 2 years, 9 women/6 men, body mass index 27 +/- 1 kg/m(2)) were evaluated. Acute hyperlipidemia was induced by a 4-h long infusion of Intralipid and heparin. Blood samples were drawn at baseline and after 2 and 4 h of acute hyperlipidemia for nonesterified fatty acids, triglycerides, and F2-isoprostanes, a biomarker of oxidative stress. Plasma nonesterified fatty acids and triglycerides increased significantly and similarly in African Americans and whites after 2 and 4 h of the Intralipid and heparin infusion. Although baseline plasma F2-isoprostanes did not differ between groups, F2-isoprostanes increased more in African Americans than in whites at 2 h (12.2 +/- 2.6 v 5.0 +/- 2.9 pg/mL, P < .05) and 4 h (13.9 +/- 3.1 v 3.0 +/- 3.0 pg/mL, P < .05) of acute hyperlipidemia. The results indicate that acute hyperlipidemia increases F2-isoprostanes more in African Americans than in whites. The findings may have important implications for ethnic differences in the prevalence of hypertension and cardiovascular and renal disease. (C) 2003 American Journal of Hypertension, Ltd.