Relationship of polyphosphoinositide metabolism to the hormonal activation of the inset salivary gland by 5-hydroxytryptamine
Relationship of polyphosphoinositide metabolism to the hormonal activation of the inset salivary gland by 5-hydroxytryptamine
复制标题
多磷酸肌醇代谢与 5-羟色胺对唾液腺激素激活的关系
DOI：
10.1016/0303-7207(84)90082-0
复制
发表时间：
1984
影响因子：
4.1
通讯作者：
J. P. Heslop
中科院分区：
文献类型：
--
作者：
M. Berridge;P. Buchan;J. P. Heslop
Incubation of the insect gland with [3H]inositol results in the incorporation of label into both phosphatidylinositol (PI) and the two polyphosphoinositides (PIP and PIP2). Upon stimulation with 5-HT the initial water-soluble metabolites released are inositol trisphosphate and inositol bisphosphate with no change in the level of inositol monophosphate, suggesting that the primary lipid substrate used by the receptor is one of the polyphosphoinositides (most likely PIP2) rather than PI. This conclusion was substantiated by showing that 5-HT was not able to release inositol or inositol monophosphate when the levels of the two polyphosphoinositides were reduced by lowering the level of ATP. The rate of breakdown of the polyphosphoinositides, as measured by the appearance of inositol phosphates, occurred with no apparent lag whereas the onset of the calcium-dependent change in transepithelial potential had a latency of approximately 1 sec. It is concluded that the primary action of 5-HT is to stimulate the hydrolysis of PIP2into diacylglycerol and inositol trisphosphate. The latter may function as a second messenger to mobilize the calcium responsible for initiating some of the ionic events responsible for fluid secretion.
肝细胞中加压素和肾上腺素诱导的磷脂酰肌醇分解是钙依赖性的。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Prpić,V;Blackmore,PF;Exton,JH
通讯作者：
Exton,JH
抗霉素 A 对大鼠腮腺受体激活钙动员和磷酸肌醇代谢的影响。
影响因子：
3.6
作者：
Poggioli,J;Weiss,SJ;McKinney,JS;PutneyJr,JW
通讯作者：
PutneyJr,JW