Cancer stem cell biomarkers for head and neck squamous cell carcinoma: A bioinformatic analysis
Cancer stem cell biomarkers for head and neck squamous cell carcinoma: A bioinformatic analysis
复制标题
头颈鳞状细胞癌的癌症干细胞生物标志物：生物信息分析
DOI：
10.3892/or.2018.6771
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发表时间：
2018-12-01
期刊：
影响因子：
4.2
通讯作者：
Wang, Yan'an
中科院分区：
文献类型：
--
作者：
Xiao, Meng;Liu, Liu;Wang, Yan'an
一些推测的生物标志物已被报道用于识别头颈部鳞状细胞癌（HNSCC）中的癌症干细胞（CSCs）。在此，我们旨在证明这些生物标志物在HNSCC中的有效性和潜在关系。基于TCGA原发性HNSCC队列，使用UCSC Xena浏览器对报道的HNSCC的CSC生物标志物进行生物信息学分析。对已验证的生物标志物的靶向策略进行了搜索和总结。共有27个已报道的HNSCC CSC生物标志物被确定并进行了综合评估。关于CD44在HNSCC中的表达模式，其余26个生物标志物的表达模式呈现3种不同的趋势。我们设法将所有27种用于HNSCC的CSC生物标志物分为3组。此外，每组的生物标志物显示了不同的临床病理特征和不同的HNSCC患者的总体生存状态。上述信息提示在HNSCC中存在CSC亚群。因此，我们证明了基于CSC亚组集群的精确靶向策略可能有效地补充常规治疗，并使HNSCC患者受益。以CSC为基础，完善HNSCC的治疗策略仍需进一步的相关研究。
Several putative biomarkers have been reported to identify cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC). Herein, we aimed to demonstrate the validity and the underlying relationship for these biomarkers in HNSCC. Bioinformatic analyses for the reported CSC biomarkers of HNSCC were performed based on the TCGA primary HNSCC cohort using the UCSC Xena browser. Targeted strategies for the validated biomarkers were searched and summarized. A total of 27 reported CSC biomarkers for HNSCC were identified and comprehensively evaluated. In regards to the expression pattern of CD44 in HNSCC, the expression patterns for the remaining 26 biomarkers presented 3 different tendencies. We managed to include all the 27 CSC biomarkers for HNSCC into 3 groups. Moreover, the biomarkers in each group indicated distinct clinicopathological features and a different overall survival status for HNSCC patients. The above information suggested the existence of CSC subpopulations in HNSCC. Accordingly, we demonstrated that precisely targeted strategies based on the CSC subgrouping clusters might effectively supplement conventional therapies, and benefit HNSCC patients. Further relevant studies are still necessary to improve treatment strategies for HNSCC based on the CSC area.