Chitosan colloidal suspension composed of mechanically disassembled nanofibers.
Chitosan colloidal suspension composed of mechanically disassembled nanofibers.
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DOI：
10.1016/j.jcis.2010.11.041
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发表时间：
2011-02
影响因子：
9.9
通讯作者：
Dagang Liu;P. Chang;Mindong Chen;Qinglin Wu
中科院分区：
文献类型：
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作者：
Dagang Liu;P. Chang;Mindong Chen;Qinglin Wu
湿磨和高压均质的联合处理，有效地分解成纳米纤维的壳聚糖颗粒之间的键的相互作用，打破壳聚糖结晶原纤维，仅使用强大的机械力。我们证明了壳聚糖纤维的尺寸减小，并表征了所获得的纳米原纤的性质和结构。结果表明，所得纳米纤维的直径约为50 nm，由直径为1- 5 nm的小束纳米原纤组成。的zeta电位，粘度和纳米纤维悬浮液的稳定性进行了研究，发现是依赖于水性介质的pH值。悬浮液的光学性质也进行了表征。在各向同性-液晶相变后，由于自取向纳米纤维的层层堆叠，壳聚糖纳米纤维胶体呈现出液晶结构。冷冻干燥的液晶胶体形状像海绵，具有宽的孔径范围和大的表面积，可以作为理想的组织支架。
Joint treatments of wet-grinding and high-pressure homogenization effectively disassembled chitosan particles into nanofibers by breaking the bond interactions between the chitosan crystalline fibrils using only strong mechanical force. We demonstrated the size reduction of chitosan fibers and characterized the properties and structure of the obtained nanofibrils. Results showed that the obtained nanofibers had a diameter of about 50nm, which comprised small bundles of nanofibrils with a diameter of 1–5nm. The zeta potential, viscosity, and stability of the nanofibrous suspension were studied and found to be dependent on the pH value of the aqueous media. Optical properties of the suspension were also characterized. After an isotropic-nematic phase transition, the chitosan nanofibrous colloids exhibited a nematic liquid crystal structure due to the layer-by-layer stacking of self-aligned nanofibers. The freeze-dried liquid crystalline colloids were shaped like a sponge with a wide-range of pore sizes and large surface areas, which could serve as an ideal tissue scaffold.