Redox Proteomics - From Protein Modifications to Cellular Dysfunction and Diseases
Redox Proteomics - From Protein Modifications to Cellular Dysfunction and Diseases
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氧化还原蛋白质组学 - 从蛋白质修饰到细胞功能障碍和疾病
DOI：
10.1002/0471973122.ch22
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Thornalley P
中科院分区：
文献类型：
--
作者：
Thornalley P
本章包含的章节标题：介绍：衍生化检测与应用于修饰的蛋白质和氨基酸；糖化，氧化和硝化氨基酸残基和游离加合物的生理来源；糖尿病中的蛋白质糖化和氧化；对细胞和细胞外蛋白的损伤尿毒学中糖化、氧化和硝化氨基酸的严重不当处理肝硬化患者血浆中糖化和氧化氨基酸增加-肝脏氧化应激的标志-阿尔茨海默病患者脑脊液中甲基乙二醛衍生的氢咪唑酮和3 -硝基酪氨酸游离加合物增加-食品和饮料中糖化加合物神经元损伤的标志糖化、氧化和硝化蛋白在疾病过程中的生理形成和蛋白水解过程——测量“损伤和碎片”的重要性
This chapter contains sections titled:Introduction: Derivatization Free Detection with Application to Modified Proteins and Amino AcidsPhysiological Sources of Glycated, Oxidized, and Nitrated Amino Acid Residues and Free AdductsProtein Glycation and Oxidation in Diabetes: Damage to Cellular and Extracellular ProteinsProfound Mishandling of Glycated, Oxidized, and Nitrated Amino Acids in UremiaIncreased Glycated and Oxidized Amino Acids of Blood Plasma in Liver Cirrhosis—A Signature of Hepatic Oxidative StressIncreased Methylglyoxal‐Derived Hydroimidazolone and 3‐Nitrotyrosine Free Adducts in Cerebrospinal Fluid of Subjects with Alzheimer's Disease—A Signature of Neuronal DamageGlycation Adducts in Food and BeveragesConcluding Remarks: Physiological Formation and Proteolytic Processing of Glycated, Oxidized, and Nitrated Proteins in Disease Processes—The Importance of Measuring “Damage and Debris”