Chemotherapy with Hybrid Liposomes Composed of Dimyristoylphosphatidylcholine and Polyoxyethylenealkyl Ether without Drugs
Chemotherapy with Hybrid Liposomes Composed of Dimyristoylphosphatidylcholine and Polyoxyethylenealkyl Ether without Drugs
复制标题
二肉豆蔻酰磷脂酰胆碱与聚氧乙烯烷基醚混合脂质体的无药化疗
DOI：
10.1021/bk-2002-0830.ch014
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
T. Kiyokawa
中科院分区：
文献类型：
--
作者：
R. Ueoka;Y. Matsumoto;H. Ichihara;T. Kiyokawa
制备了结构均匀、稳定的二肉豆蔻酰磷脂酰胆碱和聚氧乙烯烷基醚复合脂质体。在体外实验中，复合脂质体对肿瘤细胞的生长有明显的抑制作用。采用流式细胞仪和微生理仪验证了杂交脂质体通过激活caspase-3诱导细胞凋亡。杂交脂质体治疗后，接种肿瘤细胞的小鼠的存活时间明显延长，且无任何副作用。在临床应用中，静脉注射不含药物的杂化脂质体后，淋巴瘤患者的生存期延长，局部给药后实体瘤的体积显著缩小。
We produced hybrid liposomes composed of dimyristoylphosphatidylcholine and polyoxyethlenealkyl ether having the uniform and stable structure. Highly inhibitory effects of hybrid liposomes were obtained on the growth of tumor cells in vitro. Induction of apoptosis by hybrid liposomes through activation of caspase-3 was verified using flow cytometry and microphysiometer. Significantly prolonged survival was obtained in mice inoculated tumor cells after the treatment with hybrid liposomes without any side effect. In clinical applications, prolonged survival was attained in patients with lymphoma after the intravenous injection of hybrid liposomes without drugs and the remarkable reduction of solid tumor was obtained after the local administration of hybrid liposomes.