Absence of naloxone sensitivity in obese humans.
Absence of naloxone sensitivity in obese humans.
复制标题
肥胖人群不存在纳洛酮敏感性。
DOI：
10.1097/00006842-198205000-00007
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发表时间：
1982
影响因子：
3.3
通讯作者：
Ternes,JW
中科院分区：
文献类型：
--
作者：
O'Brien,CP;Stunkard,AJ;Ternes,JW
对啮齿动物的研究表明，内源性阿片活性升高与暴饮暴食和肥胖之间可能存在关联。阿片活性升高的一个量度是对阿片拮抗剂纳洛酮的敏感性。7名严重肥胖的人类受试者对大剂量静脉注射纳洛酮没有主观或生理敏感性。这一发现未能支持内啡肽活性升高与人类肥胖之间的关系。
: Studies in rodents suggest the possibility of an association between elevated endogenous opiate activity and overeating and obesity. One measure of elevated opiate activity is sensitivity to the opiate antagonist naloxone. Seven massively obese human subjects showed no subjective or physiological sensitivity to large intravenous doses of naloxone. This finding fails to support a relationship between elevated endorphin activity and human obesity.