Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation
Mapping quantal touch using 7 Tesla functional magnetic resonance imaging and single-unit intraneural microstimulation
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DOI：
10.7554/elife.12812
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发表时间：
2016-05-07
期刊：
影响因子：
7.7
通讯作者：
McGlone, Francis
中科院分区：
文献类型：
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作者：
Panchuelo, Rosa Maria Sanchez;Ackerley, Rochelle;McGlone, Francis
利用超高场7特斯拉（7T）功能磁共振成像（fMRI），我们绘制了人类正中神经单个机械感受传入单元的神经内微刺激（INMS）引发的皮层和知觉反应。将激活与振动触觉刺激单元感受野产生的激活进行比较，并分析单元类型的感知报告。我们发现，INMS和振动触觉刺激在初级体感皮层的地理上适当的数字表征中涉及重叠区域。双侧次级体感觉皮层、前运动皮层、初级运动皮层、脑岛和后顶叶皮层以及对侧前额叶皮层的其他脑区也显示出对INMS的反应被激活。INMS和7T fMRI的结合为弥合一阶机械感受性传入输入代码与其在人类皮层中的空间、动态和感知表征之间的差距提供了前所未有的机会。
Using ultra-high field 7 Tesla (7T) functional magnetic resonance imaging (fMRI), we map the cortical and perceptual responses elicited by intraneural microstimulation (INMS) of single mechanoreceptive afferent units in the median nerve, in humans. Activations are compared to those produced by applying vibrotactile stimulation to the unit's receptive field, and unit-type perceptual reports are analyzed. We show that INMS and vibrotactile stimulation engage overlapping areas within the topographically appropriate digit representation in the primary somatosensory cortex. Additional brain regions in bilateral secondary somatosensory cortex, premotor cortex, primary motor cortex, insula and posterior parietal cortex, as well as in contralateral prefrontal cortex are also shown to be activated in response to INMS. The combination of INMS and 7T fMRI opens up an unprecedented opportunity to bridge the gap between first-order mechanoreceptive afferent input codes and their spatial, dynamic and perceptual representations in human cortex.