Ubiquitin ligase CHIP suppresses cancer stem cell properties in a population of breast cancer cells
Ubiquitin ligase CHIP suppresses cancer stem cell properties in a population of breast cancer cells
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DOI：
10.1016/j.bbrc.2014.09.011
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发表时间：
2014-10-03
影响因子：
3.1
通讯作者：
Kimura, Keiji
中科院分区：
文献类型：
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作者：
Tsuchiya, Mai;Nakajima, Yuka;Kimura, Keiji
癌症干细胞（CSC）具有几个独特的特征，包括高转移潜力，肿瘤引发潜力和类似于正常干细胞的特性，如自我更新，分化和药物外排。由于这些特征，CSC被认为是负责癌症进展和患者预后。在我们之前的研究中，我们发现Hsc70相互作用蛋白（CHIP）的泛素E3连接酶羧基末端抑制乳腺癌恶性程度。此外，最近的临床研究报道，CHIP表达水平与乳腺癌患者的有利预后参数相关。在这里，我们发现CHIP抑制了乳腺癌细胞群体中的CSC特性。当使用几种测定来评估CSC特性时，CHIP消耗导致乳腺癌中CSC的比例增加。从我们的研究结果，我们提出，抑制CSC性能可能是CHIP作为癌症进展的抑制剂的功能之一。(C)2014 Elsevier Inc. All rights reserved.
Cancer stem cells (CSCs) have several distinctive characteristics, including high metastatic potential, tumor-initiating potential, and properties that resemble normal stem cells such as self-renewal, differentiation, and drug efflux. Because of these characteristics, CSC is regarded to be responsible for cancer progression and patient prognosis. In our previous study, we showed that a ubiquitin E3 ligase carboxyl terminus of Hsc70-interacting protein (CHIP) suppressed breast cancer malignancy. Moreover, a recent clinical study reported that CHIP expression levels were associated with favorable prognostic parameters of patients with breast cancer. Here we show that CHIP suppresses CSC properties in a population of breast cancer cells. CHIP depletion resulted in an increased proportion of CSCs among breast cancers when using several assays to assess CSC properties. From our results, we propose that inhibition of CSC properties may be one of the functions of CHIP as a suppressor of cancer progression. (C) 2014 Elsevier Inc. All rights reserved.