The effect of distracting noise on the neuronal mechanisms of attention in schizophrenia.
The effect of distracting noise on the neuronal mechanisms of attention in schizophrenia.
复制标题
分散注意力的噪音对精神分裂症注意力神经元机制的影响。
DOI：
10.1016/j.schres.2012.09.008
复制
发表时间：
2012
影响因子：
4.5
通讯作者：
Rojas,DonaldC
中科院分区：
文献类型：
--
作者：
Tregellas,JasonR;Smucny,Jason;Eichman,Lindsay;Rojas,DonaldC
无法忽视无关的环境噪音是精神分裂症患者的常见问题。本研究的目的是确定是否神经元对干扰噪声的反应与注意力改变的机制有关，观察到在illumination.METHODTwenty-two门诊精神分裂症患者和17名健康对照组进行了选择性注意力任务的存在或不存在的干扰环境噪声，同时进行功能磁共振成像在3 T。一个单独的条件检查被动反应的分心噪音也被included. ESTTS组的差异，在注意力的任务中的神经元反应被放大的分心噪音，与最大的差异是反应较少的患者，相对于比较科目，在颞顶交界处。与对照组相比，单独被动聆听干扰噪声导致患者海马反应更大。在所有受试者中，海马对噪声的反应与注意力任务相关网络在分散注意力的噪声中被上调以执行任务的程度呈负相关。结论鉴于观察到的海马对环境噪声的反应过度以及海马对噪声的反应与噪声对任务相关网络的影响之间的负相关关系，海马活动过度可能导致精神分裂症患者注意力网络的募集受损。
OBJECTIVEThe inability to ignore irrelevant environmental noise is a common problem for people with schizophrenia. The purpose of this study was to determine if the neuronal response to distracting noise is related to mechanisms of altered attention observed in the illness.METHODTwenty-two outpatients with schizophrenia and seventeen healthy comparison subjects performed a selective attention task in the presence or absence of distracting environmental noise while undergoing functional magnetic resonance imaging at 3T. A separate condition examining passive response to the distracting noise also was included.RESULTSGroup differences in neuronal response during the attention task were magnified by distracting noise, with the greatest difference being less response by patients, relative to comparison subjects, in the temporoparietal junction. Separate passive listening to distracting noise resulted in greater hippocampal response in patients, relative to comparison subjects. Across all subjects, hippocampal response to noise was inversely related to the degree to which the attention-task-related network was up-regulated to perform the task during distracting noise.CONCLUSIONSGiven the observed hippocampal hyperactivity in response to environmental noise in patients and the inverse relationship between hippocampal response to noise and the effects of noise on the task-related network, hippocampal hyperactivity may contribute to impaired recruitment of attention networks in schizophrenia.