An Overview of miRNAs Involved in PASMC Phenotypic Switching in Pulmonary Hypertension.
An Overview of miRNAs Involved in PASMC Phenotypic Switching in Pulmonary Hypertension.
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DOI：
10.1155/2021/5765029
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发表时间：
2021
影响因子：
--
通讯作者：
Xu R
中科院分区：
文献类型：
--
作者：
Zhang W;Tao Z;Xu F;Diao Q;Li J;Zhou L;Miao Y;Xie S;Wan J;Xu R
肺动脉高压(PH)是一种隐匿性疾病，临床表现不明显，预后差。肺血管重构是一种重要的病理特征，其中，肺血管平滑肌细胞(PASMCs)的表型转换起着至关重要的作用。MicroRNAs(MiRNAs)是一类进化高度保守的单链非编码小RNA。越来越多的研究表明，miRNAs通过调节PASMCs的表型转换在PH的发生发展中发挥重要作用，有望成为防治PH的潜在靶点。MiR-221、miR-15b、miR-96、miR-24、miR-23a、miR-9、miR-214、miR-20a等miRNAs可促进PASMCs表型转换，miR-21、miR-132、miR-449、miR-206、miR-124、miR-30c、miR-140、miR-17~92簇可抑制PASMCs表型转换。本文综述了生长因子相关miRNAs和缺氧相关miRNAs在PH中介导PASMCs表型转换的研究进展。
Pulmonary hypertension (PH) is occult, with no distinctive clinical manifestations and a poor prognosis. Pulmonary vascular remodelling is an important pathological feature in which pulmonary artery smooth muscle cells (PASMCs) phenotypic switching plays a crucial role. MicroRNAs (miRNAs) are a class of evolutionarily highly conserved single-stranded small noncoding RNAs. An increasing number of studies have shown that miRNAs play an important role in the occurrence and development of PH by regulating PASMCs phenotypic switching, which is expected to be a potential target for the prevention and treatment of PH. miRNAs such as miR-221, miR-15b, miR-96, miR-24, miR-23a, miR-9, miR-214, and miR-20a can promote PASMCs phenotypic switching, while such as miR-21, miR-132, miR-449, miR-206, miR-124, miR-30c, miR-140, and the miR-17~92 cluster can inhibit it. The article reviews the research progress on growth factor-related miRNAs and hypoxia-related miRNAs that mediate PASMCs phenotypic switching in PH.
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影响因子：
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作者：
Chistiakov DA;Sobenin IA;Orekhov AN;Bobryshev YV
通讯作者：
Bobryshev YV
DOI：
10.1016/j.omtn.2017.06.005
发表时间：
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期刊：
Molecular therapy. Nucleic acids
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影响因子：
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DOI：
10.1164/rccm.201604-0886pp
发表时间：
2017-01-15
影响因子：
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