Sphingolipids in Adipose: Kin or Foe?
Sphingolipids in Adipose: Kin or Foe?
复制标题
脂肪中的鞘脂：亲人还是敌人？
DOI：
10.1007/978-981-19-0394-6_2
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发表时间：
2022
影响因子：
--
通讯作者：
Cowart,LAshley
中科院分区：
文献类型：
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作者：
Valentine,Yolander;Cowart,LAshley
近年来，肥胖研究已经转向不仅研究个体体内脂肪组织的总量，还包括脂肪组织的功能，如内分泌功能和产热功能。数据表明，鞘脂是代谢动态平衡的关键调节器，其水平的紊乱与代谢性疾病有关。来自小鼠模型的大量数据表明，鞘脂在脂肪功能中既有有益的作用，也有有害的作用，而且大量的人类研究表明，肥胖会改变循环中的鞘脂谱。鞘脂包括一大类相互关联的代谢物，需要精确定位特定脂类的特定功能，才能充分发挥靶向鞘脂治疗肥胖和相关疾病的治疗潜力。
Obesity research has shifted in recent years to address not only the total amount of adipose tissue present in an individual but also to include adipose tissue functions such as endocrine function and thermogenesis. Data suggest that sphingolipids are critical regulators of metabolic homeostasis, and that disruption of their levels is associated with metabolic disease. Abundant data from mouse models has revealed both beneficial and deleterious roles for sphingolipids in adipose function, and numerous human studies have shown that obesity alters circulating sphingolipid profiles. Sphingolipids comprise a large family of interrelated metabolites, and pinpointing specific functions for specific lipids will be required to fully exploit the therapeutic potential of targeting sphingolipids to treat obesity and related disorders.