DIABETES, GLAUCOMA, SEX, AND CATARACT - ANALYSIS OF COMBINED DATA FROM 2 CASE CONTROL STUDIES
DIABETES, GLAUCOMA, SEX, AND CATARACT - ANALYSIS OF COMBINED DATA FROM 2 CASE CONTROL STUDIES
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DOI：
10.1136/bjo.77.1.2
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发表时间：
1993-01-01
影响因子：
4.1
通讯作者：
HARDING, RS
中科院分区：
文献类型：
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作者：
HARDING, JJ;EGERTON, M;HARDING, RS
对牛津郡两个病例对照研究的数据进行了合并和分析。这项联合研究涵盖了1940名受试者，723名病例和1217名对照，年龄在50岁到79岁之间，病例的应答率为97%，对照组的应答率为94%。糖尿病被证明是白内障的一个强大和高度显著的危险因素，相对风险为5-04。牛津郡超过11%的白内障可归因于糖尿病。在50~79岁的年龄范围内，相对危险度没有显着增加，但女性的相对危险度高于男性。女性糖尿病患者的相对危险度为7-85，95%可信区间为4.30-14.3；男性糖尿病患者的相对危险度为3.42，可信区间为2.05-5.71。当其他已确定的危险因素被控制后，糖尿病仍然是一个强大的危险因素。目前尚无已知的糖尿病并发症发生机制能解释女性患病风险过高的原因。这两项研究的结合导致了对青光眼作为白内障风险因素的相对风险的更好估计(3-96，95%可信区间2.35-6-68)。女性的相对风险似乎比男性更大，但这种差异在统计学上并不显着。随着年龄的增长，风险没有显著变化。青光眼是男女白内障的一个强大而独立的危险因素，可能是我们地区所有白内障的5%的原因。
Data from two case control studies in Oxfordshire were combined and analysed. The combined study covered 1940 subjects, 723 cases, and 1217 controls, between the ages of 50 and 79 with a response rate of 97% for cases and 94% for controls. Diabetes was shown to be a powerful and highly significant risk factor for cataract with a relative risk of 5-04. More than 11% of cataracts in Oxfordshire are attributable to diabetes. The relative risk did not increase significantly with age within the range 50 to 79 years but was higher in females than in males. For females with diabetes the relative risk was 7-85 with 95% confidence interval from 4.30 to 14.3 compared with 3.42 with confidence interval from 2.05 to 5.71 for males with diabetes. Diabetes remained a powerful risk factor when other identified risk factors had been controlled for. No known mechanism for the development of diabetic complications provides an explanation for the excess risk in females. Combination of the two studies led to better estimates of the relative risk of glaucoma as a risk factor for cataract (3-96 with 95% confidence interval from 2.35 to 6-68). The relative risk appeared to be greater in women than in men but this difference was not statistically significant. There was no significant change in risk with age. Glaucoma is a powerful and independent risk factor for cataract in both sexes and may be responsible for 5% of all cataracts in our area.