Cyclic nucleotides vary by area in the retina and pigmented epithelium of the human and monkey.
Cyclic nucleotides vary by area in the retina and pigmented epithelium of the human and monkey.
复制标题
人类和猴子的视网膜和色素上皮中的环核苷酸因区域而异。
DOI：
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发表时间：
1980
影响因子：
4.4
通讯作者：
G. Chader
中科院分区：
文献类型：
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作者：
D. Newsome;R. Fletcher;G. Chader
环GMP和环AMP在人和猴的神经视网膜的中央（黄斑）区域中的浓度低于其他区域。这种模式近似于视杆细胞的分布。令人惊讶的是，在色素上皮中观察到环GMP浓度的反向梯度。中心区域的水平比周围细胞的水平高四倍以上，这首次证明了这种胚胎学上均匀的细胞类型的生化差异。
Cyclic GMP and cyclic AMP are present in lower concentrations in the central (macular) region of the neural retina of the human and monkey than in other areas. This pattern approximates the distribution of rod photoreceptor cells. Surprisingly, an inverse gradient of cyclic GMP concentration is observed in the pigmented epithelium. Levels in the central region are over fourfold higher than in cells in the periphery, offering the first evidence of biochemical differences in this embryologically uniform cell type.