Radiation-induced genomic instability and its implications for radiation carcinogenesis
Radiation-induced genomic instability and its implications for radiation carcinogenesis
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DOI：
10.1038/sj.onc.1206697
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发表时间：
2003-09-01
期刊：
影响因子：
8
通讯作者：
Morgan, WF
中科院分区：
文献类型：
--
作者：
Huang, L;Snyder, AR;Morgan, WF
辐射诱导的基因组不稳定性的特征是遗传改变的速率增加，包括细胞遗传学重排、突变、基因扩增、转化和在初始损伤后多代辐射细胞的后代中的细胞死亡。染色体重排是辐射诱导的基因组不稳定性的最佳特征终点，所描述的许多重排与人类癌症中发现的重排相似。染色体断裂综合征由染色体不稳定性定义，患有这些疾病的个体容易患癌症。因此，染色体不稳定性作为一种表型可能是导致癌症的那些变化的一部分的基础。在这里，我们试图将目前的知识辐射引起的染色体不稳定性与染色体断裂综合征的新兴分子信息。目的是了解遗传和表观遗传因素如何影响染色体不稳定性的发生以及染色体不稳定性在致癌作用中的作用。
Radiation-induced genomic instability is characterized by an increased rate of genetic alterations including cytogenetic rearrangements, mutations, gene amplifications, transformation and cell death in the progeny of irradiated cells multiple generations after the initial insult. Chromosomal rearrangements are the best-characterized end point of radiation-induced genomic instability, and many of the rearrangements described are similar to those found in human cancers. Chromosome breakage syndromes are defined by chromosome instability, and individuals with these diseases are cancer prone. Consequently, chromosomal instability as a phenotype may underlie some fraction of those changes leading to cancer. Here we attempt to relate current knowledge regarding radiation-induced chromosome instability with the emerging molecular information on the chromosome breakage syndromes. The goal is to understand how genetic and epigenetic factors might influence the onset of chromosome instability and the role of chromosomal instability in carcinogenesis.