Impact of head and neck malignancies on risk factors and survival in systemic lupus erythematosus
Impact of head and neck malignancies on risk factors and survival in systemic lupus erythematosus
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DOI：
10.3109/00016489.2013.800228
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发表时间：
2013-10-01
影响因子：
1.4
通讯作者：
Lin, Yung-Song
中科院分区：
文献类型：
--
作者：
Chang, Shih-Lun;Hsu, Hsin-Te;Lin, Yung-Song
结论：系统性红斑狼疮(SLE)与发生头颈部恶性肿瘤(HNM)的风险增加有关。系统性红斑狼疮病史对我们的研究队列在癌症发展后的存活率没有显著影响。目的：探讨系统性红斑狼疮(SLE)患者发生恶性黑色素瘤的风险和生存率。方法：这是一项基于人群的回溯性队列研究。我们比较了2001-2008年间新诊断的SLE患者(n=8751)和年龄匹配的对照组(1：10)(n=87510)。然后确定了2009年底HNMS的发病率。结果：我们发现在确诊为SLE的患者中，HNMS的风险是年龄匹配的对照组中首次恶性肿瘤风险的2.16倍(发病率比，IRR=2.16，p<；0.05)。SLE患者HNMS发生率最高的部位是口腔(5/11，45.45%)，其次是鼻咽(4/11，36.36%)。与使用新的HNM的年龄匹配的对照组相比，系统性红斑狼疮患者使用新的HNM对生存没有协同作用(p=0.2446)。
Conclusions: Systemic lupus erythematosus (SLE) is associated with an increased risk of developing a head and neck malignancy (HNM). A history of SLE did not significantly impact the survival of our study cohort after cancer developed. Objectives: To examine the risk and survival rates of HNM in patients with SLE. Methods: This was a population-based, retrospective cohort study. We compared patients newly diagnosed with SLE between 2001 and 2008 (n = 8751) with age-matched controls (1: 10) (n = 87 510). The incidence of HNMs at the end of 2009 was then determined. Results: We found a 2.16-fold higher risk of HNMs in patients diagnosed with SLE compared with the risk of first malignancy in the age-matched controls (incidence rate ratio, IRR = 2.16, p < 0.05). The site with the highest incidence of HNMs in SLE patients was the oral cavity (5/11, 45.45%), followed by the nasopharynx (4/11, 36.36%). SLE displayed no synergic effect on the survival of SLE patients with an HNM compared with age-matched controls with a new HNM (p = 0.2446).