Effectiveness of add-on low-dose diuretics in combination therapy for hypertension: Losartan/hydrochlorothiazide vs. candesartan/amlodipine
Effectiveness of add-on low-dose diuretics in combination therapy for hypertension: Losartan/hydrochlorothiazide vs. candesartan/amlodipine
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DOI：
10.1291/hypres.30.831
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发表时间：
2007-09-01
影响因子：
5.4
通讯作者：
Fujita, Toshiro
中科院分区：
文献类型：
--
作者：
Shimosawa, Tatsuo;Gohchi, Kengo;Fujita, Toshiro
在指南中，两种或多种抗高血压药物的联合治疗被推荐用于治疗单药治疗无效的高血压。虽然利尿剂或钙通道阻滞剂通常用作血管紧张素受体阻滞剂（ARB）的辅助药物，但尚未确定最有效和最安全的联合用药。在这项为期4个月的随机研究中，比较了ARB/利尿剂（氯沙坦/氢氯噻嗪[HCTZ]）联合用药与最常用的处方药联合用药ARB/钙通道阻滞剂（坎地沙坦/曲马多）在8 mg/天坎地沙坦无效的高血压患者中的疗效和安全性。将36例患者分为两组，其中16例患者接受氯沙坦（50 mg/d）/HCTZ（12.5 mg/d）治疗（L/H组），15例患者接受坎地沙坦（8 mg/d）/氨碘平（5 mg/d）治疗（C/A组）。4个月后，UH显著（p
In guidelines, a combination therapy of two or more antihypertensives is recommended for treatment of hypertension where monotherapy is ineffective. Although diuretics or calcium channel blockers are commonly used as add-ons to angiotensin receptor blocker (ARB), the most effective and safe combination has not been established. In this randomized 4-month study, the efficacy and safety were compared between an ARB/diuretics (losartan/hydrochlorothiazide [HCTZ]) combination and the most prescribed combination, ARB/calcium channel blocker (candesartan/amlodipine) in hypertensive patients for whom 8 mg/day of candesartan proved ineffective. After 36 patients were recruited and allocated into two groups, changes in blood pressure (BP) and laboratory values were analyzed in 31 patients: 16 patients received losartan (50 mg/day)/HCTZ (12.5 mg/day) (L/H group), and 15 patients received candesartan (8 mg/day)/amiodipine (5 mg/day) (C/A group) after 5 patients were withdrawn. After 4 months, UH significantly (p