Fearful symmetry: subversion of asymmetric division in cancer development and progression.
Fearful symmetry: subversion of asymmetric division in cancer development and progression.
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DOI：
10.1158/0008-5472.can-14-2750
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发表时间：
2015-03-01
期刊：
影响因子：
11.2
通讯作者：
Reya T
中科院分区：
文献类型：
--
作者：
Bajaj J;Zimdahl B;Reya T
不对称分裂是一个进化上保守的过程，通过命运决定子的不平等分配产生具有不同命运的子细胞。虽然不对称分裂在发育过程中产生多样性特别重要，但其失调也可促进肿瘤发生。特别是，改变对称和不对称分裂的正常平衡的信号可以导致分化停滞并触发癌症进展。在这里，我们讨论的研究，提供了越来越多的支持这一想法：从最初的工作在果蝇进行，我们跟踪最近的数据在哺乳动物系统中，这表明，颠覆不对称分裂可以显着促进血液系统恶性肿瘤和实体癌的发展和进展。
Asymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants. While asymmetric division is particularly important in generating diversity during development, its dysregulation can also promote oncogenesis. In particular, signals that shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression. Here we discuss the studies that have provided increasing support for this idea: beginning with original work carried out in Drosophila, we trace more recent data in mammalian systems that suggest that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers.