Immunomodulation at the initiation of phototherapy and photochemotherapy
Immunomodulation at the initiation of phototherapy and photochemotherapy
复制标题
光疗和光化疗开始时的免疫调节
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
M. Norval
中科院分区：
文献类型：
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作者：
M. Guckian;C. D. Jones;J. Vestey;E. J. Cooper;R. S. Dawe;N. K. Gibbs;M. Norval
银屑病患者循环淋巴细胞亚群的数量和功能在正常范围内，并且不受4周紫外线（UV）治疗的影响，除了抑制自然杀伤（NK）细胞活性。然而，免疫调节可能在光疗开始时发生，在更长时间的UV暴露后恢复到对照值。因此，在这项研究中，比较了15名接受宽带UVB治疗、10名接受窄带（311-313 nm）UVB治疗和10名接受PUVA治疗的慢性斑块状银屑病患者的反应。在每种情况下，在开始给药前即刻和1周后采集样本。宽带UVB和PUVA治疗对NK活性没有影响，但在接受窄带UVB的组中发现了显著降低。在体外淋巴细胞增殖反应的有丝分裂原和单纯疱疹病毒抗原没有改变治疗，除了有一个显着增加有丝分裂原反应（仅在最佳有丝分裂原浓度）在窄带UVB组。一般而言，在任何组中均未发现循环单核细胞的总体百分比发生变化。从接受窄谱UVB的患者的前臂和背部的表皮采集样品，用于定量尿刊酸（UCA）异构体。治疗1周后，总UCA浓度保持不变，而大多数患者两个部位的顺式UCA百分比均显著增加。然而，这种上升并没有与NK细胞活性的下降，这两个参数可能没有因果关系。
The numbers and function of circulating lymphocyte subsets are within normal ranges in patients with psoriasis and are not affected by 4 weeks of ultraviolet (UV) therapy, except for a suppression in natural killer (NK) cell activity. However, it is possible that immunomodulation might occur at the initation of phototherapy with a return to control values on more prolonged UV exposure. Thus, in this study the responses of 15 patients with chronic plaque psoriasis undergoing broad‐band UVB therapy, 10 narrow‐band (311–313 nm) UVB therapy and 10 PUVA therapy were compared. In each case, samples were taken immediately before starting treatment and 1 week later. Broad‐band UVB and PUVA therapy had no effect on NK activity, but a significant reduction was found in the group receiving narrow‐band UVB. In vitro lymphoproliferative responses to mitogens and to herpes simplex virus antigens did not alter with therapy, except there was a significant increase in mitogen responses (at optimal mitogen concentrations only) in the narrow‐band UVB group. Generally no alterations in overall percentages of circulating mononuclear cells were found in any group. Samples were taken from the epidermis of the forearm and back of the patients receiving narrow‐band UVB for the quantification of urocanic acid (UCA) isomers. The total UCA concentration remained unchanged after 1 week of therapy, while the percentage of cis‐UCA increased significantly at both sites in the majority of patients. However, this rise did not correlate with the decrease in NK cell activity and the two parameters may not be related causally.
紫外线照射的角质形成细胞上清液对迟发型超敏反应的全身抑制。
DOI：
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发表时间：
1992
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Rivas,JM;Ullrich,SE
通讯作者：
Ullrich,SE