Bilateral common carotid artery ligation transiently changes brain lipid metabolism in rats.
Bilateral common carotid artery ligation transiently changes brain lipid metabolism in rats.
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DOI：
10.1007/s11064-012-0740-2
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发表时间：
2012-07
影响因子：
4.4
通讯作者：
Rapoport, Stanley I.
中科院分区：
文献类型：
--
作者：
Bhattacharjee, Abesh Kumar;White, Laura;Chang, Lisa;Ma, Kaizong;Harry, G. Jean;Deutsch, Joseph;Rapoport, Stanley I.
Brain lipid metabolism was studied in rats following permanent bilateral common carotid artery ligation (BCCL), a model for chronic cerebral hypoperfusion. Unesterified (free) fatty acids (uFA) and acyl-CoA concentrations were measured 6 h, 24 h, and 7 days after BCCL or sham surgery, in high energy-microwaved brain. In BCCL compared to sham rats, cPLA2 immunoreactivity in piriform cortex, and concentrations of total uFA and arachidonoyl-CoA, an intermediate for arachidonic acid reincorporation into phospholipids, were increased only at 6 h. At 24 h, immunoreactivity for secretory phospholipase A2 (sPLA2), which may regulate blood flow, was increased near cortical and hippocampal blood vessels. BCCL did not affect difference brain IB4+ microglia, glial fibrillary acidic protein (GFAP)+ astrocytes, cyclooxygenase-2 (COX-2) immunoreactivity at any time, but increased cytosolic cPLA2 immunoreactivity in one region at 6 h. Thus, BCCL affected brain lipid metabolism transiently, likely because of compensatory sPLA2-mediated vasodilation, without producing evidence of neuroinflammation.
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影响因子：
2.9
作者：
KOVALCHUK, Y;MILLER, B;ATTWELL, D
通讯作者：
ATTWELL, D
影响因子：
5
作者：
Institoris, Adam;Farkas, Eszter;Bari, Ferenc
通讯作者：
Bari, Ferenc
影响因子：
2.9
作者：
Farkas, B;Tantos, A;Friedrich, P
通讯作者：
Friedrich, P
DOI：
10.1254/jjp.28.277
发表时间：
1978-01-01
期刊：
JAPANESE JOURNAL OF PHARMACOLOGY
影响因子：
--
作者：
KUWASHIMA, J;NAKAMURA, K;SHIMIZU, M
通讯作者：
SHIMIZU, M
影响因子：
4.4
作者：
Deutsch, J;Rapoport, SI;Purdon, AD
通讯作者：
Purdon, AD