Biocompatible and pH-Responsive Colloidal Surfactants with Tunable Shape for Controlled Interfacial Curvature
Biocompatible and pH-Responsive Colloidal Surfactants with Tunable Shape for Controlled Interfacial Curvature
复制标题
具有可调节形状以控制界面曲率的生物相容性和 pH 响应性胶体表面活性剂
DOI：
10.1002/anie.202001588
复制
发表时间：
2020-04-06
影响因子：
16.6
通讯作者：
Liu, Kai
中科院分区：
文献类型：
--
作者：
Sun, Zhu;Yang, Chenjing;Liu, Kai
分子表面活性剂稳定的乳剂易发生聚结和奥斯特瓦尔德成熟。两亲性颗粒在界面处具有更强的锚定强度，可以有效地缓解这些问题，形成稳定的皮克林乳液。在此，我们描述了一种通过控制共沉淀和相分离来制备生物相容性两亲二聚体颗粒的通用方法。二聚体颗粒由疏水性聚乳酸球和亲水性紫胶-聚乙二醇球组成，因此类似于非离子分子表面活性剂。二聚体颗粒的大小和直径比很容易调节，可以灵活地控制水/油界面曲率，从而控制乳液的类型。颗粒稳定的乳剂在很长一段时间内是稳定的，并且可以通过ph触发的反应而不稳定。具有可调形态和功能的生物相容性两亲二聚体颗粒因此是各种应用的理想胶体表面活性剂。
Molecular-surfactant-stabilized emulsions are susceptible to coalescence and Ostwald ripening. Amphiphilic particles, which have a much stronger anchoring strength at the interface, could effectively alleviate these problems to form stable Pickering emulsions. Herein, we describe a versatile method to fabricate biocompatible amphiphilic dimer particles through controlled coprecipitation and phase separation. The dimer particles consist of a hydrophobic PLA bulb and a hydrophilic shellac-PEG bulb, thus resembling nonionic molecular surfactants. The size and diameter ratio of the dimer particles are readily tunable, providing flexible control over the water/oil interfacial curvature and thus the type of emulsion. The particle-stabilized emulsions were stable for a long period of time and could be destabilized through a pH-triggered response. The biocompatible amphiphilic dimer particles with tunable morphology and functionality are thus ideal colloidal surfactants for various applications.