The Functions of MicroRNA-200 Family in Ovarian Cancer: Beyond Epithelial-Mesenchymal Transition.
The Functions of MicroRNA-200 Family in Ovarian Cancer: Beyond Epithelial-Mesenchymal Transition.
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MicroRNA-200家族在卵巢癌中的功能：超越上皮-间充质转化。
DOI：
10.3390/ijms18061207
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发表时间：
2017-06-06
影响因子：
5.6
通讯作者：
Ng SW
中科院分区：
文献类型：
--
作者：
Choi PW;Ng SW
大多数关于人类癌症中 microRNA-200 家族成员 (miR-200s) 的研究都是基于以下前提：miR-200s 通过直接抑制间充质转录因子锌指 E 盒结合同源框 1/2 (ZEB1/ZEB2) 和转化生长因子-β (TGF-β) 来抑制上皮间质转化 (EMT)，从而维持上皮细胞完整性。 EMT 的有效诱导剂。因此，癌细胞中miR-200的下调促进EMT和癌症转移。然而，miR-200 在卵巢癌中高表达，并且卵巢癌主要通过盆腔内播散进行转移。在这篇综述中，我们将重新关注卵巢癌细胞的上皮特性和 miR-200 在保护该特性中的作用，以及 miR-200 在包涵囊肿形成、癌细胞生长、集体运动、血管生成、外泌体介导的细胞通讯和化学反应中的多种作用。综上所述，miR-200 在卵巢癌的发生、进展和转移中发挥着重要作用，并可作为诊断生物标志物和治疗开发的靶点。
The majority of studies on microRNA-200 family members (miR-200s) in human cancers are based on the premise that miR-200s maintain epithelial cell integrity by suppressing epithelial-mesenchymal transition (EMT) through direct inhibition of mesenchymal transcription factors zinc finger E-box-binding homeobox 1/2 (ZEB1/ZEB2) and transforming growth factor-β (TGF-β), a potent inducer of EMT. Hence, downregulation of miR-200 in cancer cells promotes EMT and cancer metastasis. Yet, miR-200s are highly expressed in ovarian cancer, and ovarian cancer metastasizes primarily by dissemination within the pelvic cavity. In this review, we will refocus the epithelial property of ovarian cancer cells and the role of miR-200s in safeguarding this property, as well as the diverse roles of miR-200s in inclusion cyst formation, cancer cell growth, collective movement, angiogenesis, exosome-mediated cell communication, and chemoresponse. Taken together, miR-200s play a significant role in the initiation, progression and metastasis of ovarian cancer and may serve as diagnostic biomarkers and a target in therapeutic development.