Diverse Cell Populations Involved in Regeneration of Renal Tubular Epithelium following Acute Kidney Injury.
Diverse Cell Populations Involved in Regeneration of Renal Tubular Epithelium following Acute Kidney Injury.
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DOI：
10.1155/2015/964849
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发表时间：
2015
影响因子：
4.3
通讯作者：
Nojima Y
中科院分区：
文献类型：
--
作者：
Maeshima A;Takahashi S;Nakasatomi M;Nojima Y
肾小管上皮具有响应各种损伤而再生、修复和再上皮化的能力。先前对几种肾损伤模型的研究表明，多种生长因子、转录因子和细胞外基质参与了这一过程。存活的肾小管细胞在损伤后的肾脏再生过程中活跃地增殖、迁移和分化，并且一些细胞表达推定的干细胞标记物或具有干细胞特性。使用命运图谱技术，骨髓来源的细胞和内皮祖细胞已被证明可以在体内或离体转分化为肾小管成分。类似地，已经证明，在肾小管细胞再生过程中，一些炎症细胞群迁移、聚集在肾小管细胞周围，并在肾小管上皮修复过程中与肾小管细胞相互作用。在这篇综述中，我们描述了理解肾小管再生机制的最新进展，特别是有助于肾小管再生的各种细胞群的特征，并强调了治疗人类肾脏疾病的再生医学的发展目标。
Renal tubular epithelium has the capacity to regenerate, repair, and reepithelialize in response to a variety of insults. Previous studies with several kidney injury models demonstrated that various growth factors, transcription factors, and extracellular matrices are involved in this process. Surviving tubular cells actively proliferate, migrate, and differentiate in the kidney regeneration process after injury, and some cells express putative stem cell markers or possess stem cell properties. Using fate mapping techniques, bone marrow-derived cells and endothelial progenitor cells have been shown to transdifferentiate into tubular components in vivo or ex vivo. Similarly, it has been demonstrated that, during tubular cell regeneration, several inflammatory cell populations migrate, assemble around tubular cells, and interact with tubular cells during the repair of tubular epithelium. In this review, we describe recent advances in understanding the regeneration mechanisms of renal tubules, particularly the characteristics of various cell populations contributing to tubular regeneration, and highlight the targets for the development of regenerative medicine for treating kidney diseases in humans.
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DOI：
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发表时间：
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影响因子：
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