A wireless recording system that utilizes Bluetooth technology to transmit neural activity in freely moving animals
A wireless recording system that utilizes Bluetooth technology to transmit neural activity in freely moving animals
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DOI：
10.1016/j.jneumeth.2009.06.007
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发表时间：
2009-09-15
影响因子：
3
通讯作者：
Deadwyler, Sam A.
中科院分区：
文献类型：
--
作者：
Hampson, Robert E.;Collins, Vernell;Deadwyler, Sam A.
描述了一种新的无线收发器，用于利用蓝牙传输技术和板载处理器来记录行为老鼠的单个神经元放电，以区分神经元波形和相关时间戳。这种通用大脑活动发射器 (UBAT) 通过背包和放大器探头连接到啮齿动物，并可以通过蓝牙收发器芯片在非常大且不受限制的距离上传输 16 通道捕获的神经元放电数据。 UBAT 的板载微处理器允许通过收发器指令灵活地在线控制波形隔离标准，并且双向通信能力允许神经事件和行为或生理过程之间的闭环应用，这些过程可以通过收发器指令进行修改。提供了通道数据的多路复用器处理的详细描述以及不同行为测试环境中神经元记录的示例，以证明在几乎任何实验室环境中稳健传输的能力。 UBAT 的主要优点是传输距离长，并且没有蓝牙技术提供的基于物体的视线干扰，从而可以在多个实验范式中实现灵活的记录功能而不会中断。与监测站相隔很远距离的连续记录被证明为实验者提供了以前其他遥测设备所没有的记录优势。 (C) 2009 Elsevier B.V. 保留所有权利。
A new wireless transceiver is described for recording individual neuron firing from behaving rats utilizing Bluetooth transmission technology and a processor onboard for discrimination of neuronal waveforms and associated time stamps. This universal brain activity transmitter (UBAT) is attached to rodents via a backpack and amplifier headstage and can transmit 16 channels of captured neuronal firing data via a Bluetooth transceiver chip over very large and unconstrained distances. The onboard microprocessor of the UBAT allows flexible online control over waveform isolation criteria via transceiver instruction and the two-way communication capacity allows for closed-loop applications between neural events and behavioral or physiological processes which can be modified by transceiver instructions. A detailed description of the multiplexer processing of channel data as well as examples of neuronal recordings in different behavioral testing contexts is provided to demonstrate the capacity for robust transmission within almost any laboratory environment. A major advantage of the UBAT is the long transmission range and lack of object-based line of sight interference afforded by Bluetooth technology, allowing flexible recording capabilities within multiple experimental paradigms without interruption. Continuous recordings over very large distance separations from the monitor station are demonstrated providing experimenters with recording advantages not previously available with other telemetry devices. (C) 2009 Elsevier B.V. All rights reserved.