Distinguishing pathological from constitutional small for gestational age births in population-based studies
Distinguishing pathological from constitutional small for gestational age births in population-based studies
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DOI：
10.1016/j.earlhumdev.2009.09.004
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发表时间：
2009-10-01
影响因子：
2.5
通讯作者：
Vintzileos, Anthony M.
中科院分区：
文献类型：
--
作者：
Ananth, Cande V.;Vintzileos, Anthony M.
背景：小于胎龄（SGA）可能发生在病理过程之后，或者可能代表胎儿体质较小。然而，区分这些过程通常很困难，尤其是在大型研究中，术语 SGA 经常被用作胎儿生长受限的代表。由于胎儿大小的生物学变化主要是妊娠晚期的现象。我们假设足月 SGA 的定义可能包括相当大比例的体质较小的胎儿。相反，由于（早期）早产妊娠中胎儿大小的生物学变异并未完全表达，因此早期早产妊娠中的 SGA 可能会包含很大一部分生长受限胎儿。 目的：我们比较了 SGA 和适合胎龄 (AGA) 婴儿之间的死亡率和发病率。 对象：一项基于人口的研究，针对 1900 万以上的非畸形单胎出生（1995-04）美国进行了。胎龄（24-44 周）基于临床估计。 SGA 和 AGA 被定义为特定性别的出生体重
Background: Small for gestational age (SGA) can occur following a pathological process or may represent constitutionally small fetuses. However, distinguishing these processes is often difficult, especially in large studies, where the term SGA is often used as a proxy for restricted fetal growth. Since biologic variation in fetal size is largely a third trimester phenomenon. we hypothesized that the definition of SGA at term may include a sizeable proportion of constitutionally small fetuses. in contrast, since biologic variation in fetal size is not fully expressed in (early) preterm gestations, it is plausible that SGA in early preterm gestations would comprise a large proportion of growth restricted fetuses.Aim: We compared mortality and morbidity rates between SGA and appropriate for gestational age (AGA) babies.Subjects: A population-based study of over 19 million non-malformed, singleton births (1995-04) in the United States was performed. Gestational age (24-44 weeks) was based on a clinical estimate. SGA and AGA were defined as sex-specific birthweight