Chronic multi-electrode neural recording in free-roaming monkeys
Chronic multi-electrode neural recording in free-roaming monkeys
复制标题
DOI：
10.1016/j.jneumeth.2008.04.029
复制
发表时间：
2008-07-30
影响因子：
3
通讯作者：
Wang, Xiaoqin
中科院分区：
文献类型：
--
作者：
Eliades, Steven J.;Wang, Xiaoqin
神经生理学家感兴趣的许多行为很难在实验室条件下进行研究，因为当动物受到限制和社会孤立时，这些行为通常会受到抑制。即使在最佳条件下，这种行为也可能足够稀疏，以至于需要长时间的神经记录或多个神经元的同时记录来收集足够量的数据用于分析。我们已经开发了一种制备慢性，多电极记录在听觉皮层的绒猴，小灵长类动物，以及神经生理学记录的技术，当动物是自由漫游，而单独关在笼子里的环境中的猴群。在这份报告中，我们描述了我们的解决方案，以克服与自由漫游动物的慢性记录，其中三维运动提出了特殊的挑战相关的问题。(c)2008 Elsevier B.V.保留所有权利。
Many behaviors of interest to neurophysiologists are difficult to study under laboratory conditions because such behaviors are often inhibited when an animal is restrained and socially isolated. Even under the best conditions, such behaviors may be sparse enough as to require long duration neural recordings or simultaneous recording of multiple neurons to gather a sufficient amount of data for analysis. We have developed a preparation for chronic, multi-electrode recordings in the auditory cortex of marmoset monkeys, small primates, as well as techniques for neurophysiological recordings when the animals are free-roaming while singly caged in the environment of the monkey colony. In this report, we describe our solutions to overcome the problems associated with chronic recordings in free-roaming animals, where three-dimensional movements present particular challenges. (c) 2008 Elsevier B.V. All rights reserved.