Applying linked data approaches to pharmacology: Architectural decisions and implementation
Applying linked data approaches to pharmacology: Architectural decisions and implementation
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DOI：
10.3233/sw-2012-0088
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发表时间：
2014-01-01
期刊：
影响因子：
3
通讯作者：
Williams, Antony J.
中科院分区：
文献类型：
--
作者：
Gray, Alasdair J. G.;Groth, Paul;Williams, Antony J.
新药的发现需要药理学家与许多信息来源互动，从表格数据到科学论文，以及其他专门的格式。在这份应用报告中，我们描述了一个关联数据平台，用于集成多个药理学数据集，这些数据集构成了几个药物发现应用的基础。该平台提供的功能来自一系列优先的药物发现业务问题，这些问题是作为Open PHACTS项目的一部分创建的，该项目是研究机构和主要制药公司的合作。我们描述了平台的体系结构，重点介绍了驱动其开发的七个设计决策，目的是通知其他在该领域或其他领域开发类似软件的人。OPS平台的阿尔法版本目前可供Open PHACTS联盟使用，第一个公开版本将于2012年底发布。
The discovery of new medicines requires pharmacologists to interact with a number of information sources ranging from tabular data to scientific papers, and other specialized formats. In this application report, we describe a linked data platform for integrating multiple pharmacology datasets that form the basis for several drug discovery applications. The functionality offered by the platform has been drawn from a collection of prioritised drug discovery business questions created as part of the Open PHACTS project, a collaboration of research institutions and major pharmaceutical companies. We describe the architecture of the platform focusing on seven design decisions that drove its development with the aim of informing others developing similar software in this or other domains. The utility of the platform is demonstrated by the variety of drug discovery applications being built to access the integrated data.An alpha version of the OPS platform is currently available to the Open PHACTS consortium and a first public release will be made in late 2012.