A signal-averaging technique for the analysis of human muscle sympathetic nerve activity.
A signal-averaging technique for the analysis of human muscle sympathetic nerve activity.
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用于分析人体肌肉交感神经活动的信号平均技术。
DOI：
10.1152/jappl.1992.73.1.376
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Rea,RF
中科院分区：
文献类型：
--
作者：
Birkett,CL;Ray,CA;Anderson,EA;Rea,RF
我们提出了一种分析人体肌肉交感神经活动（SNA）的信号平均技术。通过耦合信号采集和心电图R波来平均神经流量。将平均波形的振幅乘以采样的R波的数量，以任意单位提供SNA的度量。这与手工数字化硬拷贝记录测量的SNA进行了比较。在9名志愿者中，通过逐步输注硝普赛或苯肾上腺素，SNA升高或降低：每个受试者有10个5分钟的数据周期。在所有受试者中，在硝普塞（r = 0.98）和苯肾上腺素（r = 0.91）输注期间，人工和信号平均测量的SNA之间的相关性都很好，回归线的斜率接近一致。在三个数据收集周期中，在将信号重放到计算机中期间，以0.5和0.07 Hz的频率随机添加电子伪影。SNA的信号平均估计不受人为影响。这种技术提供了可靠的独立于观察者的SNA度量。
We present a signal-averaging technique for analysis of human muscle sympathetic nerve activity (SNA). Nerve traffic was averaged by coupling signal acquisition to electrocardiographic R waves. The amplitude of the averaged waveform was multiplied by the number of R waves sampled to provide a measure of SNA in arbitrary units. This was compared with SNA measured by manual digitization of hard-copy records. In nine volunteers, SNA was increased or decreased with stepwise infusions of nitroprusside or phenylephrine: there were 10 5-min periods of data in each subject. Across all subjects, the correlation between manual and signal-averaged measures of SNA was excellent during both nitroprusside (r = 0.98) and phenylephrine infusions (r = 0.91) and the slopes of the regression lines were near unity. In three periods of data collection, electrical artifacts were added randomly at frequencies of 0.5 and 0.07 Hz during playback of the signal into the computer. Signal-averaged estimates of SNA were unaffected by artifacts. This technique provides reliable observer-independent measures of SNA.