Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania
Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania
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DOI：
10.1016/j.lfs.2006.01.002
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发表时间：
2006-06-13
期刊：
影响因子：
6.1
通讯作者：
Kapczinski, Flavio
中科院分区：
文献类型：
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作者：
Frey, Benicio N.;Andreazza, Ana C.;Kapczinski, Flavio
有一个新兴的数据表明，情绪障碍与脑源性神经营养因子（BDNF）减少有关。本研究旨在探讨情绪稳定剂锂（Li）和丙戊酸盐（VPT）在双相情感障碍动物模型中的作用。在第一个实验（急性治疗）中，大鼠给予D-苯丙胺（AMPH）或盐水14天，然后在第8天至第14天之间，大鼠用Li、VPT或盐水治疗。在第二个实验（维持治疗）中，大鼠用Li、VPT或生理盐水预处理，然后在第8天至第14天之间，大鼠被施用AMPH或生理盐水。在这两个实验中，自发活动进行了测量，使用开放领域的测试和BDNF水平进行了测量，在大鼠海马通过ELISA。在两个实验中，Li和VPT在旷场测试中逆转了AMPH诱导的行为效应。在第一个实验中，Li增加了大鼠海马中BDNF的水平。在第二个实验中，AMPH降低大鼠海马BDNF水平，Li和VPT升高大鼠海马BDNF水平。我们的研究结果表明，本模型满足足够的面子，结构和预测效度作为躁狂症的动物模型。(c)2006年爱思唯尔公司All rights reserved.
There is an emerging body of data suggesting that mood disorders are associated with decreased brain-derived neurotrophic factor (BDNF). The present study aims to investigate the effects of the mood stabilizers lithium (Li) and valproate (VPT) in an animal model of bipolar disorder. In the first experiment (acute treatment), rats were administered D-amphetamine (AMPH) or saline for 14 days, and then between day 8 and 14, rats were treated with either Li, VPT or saline. In the second experiment (maintenance treatment), rats were pretreated with Li, VPT or saline, and then between day 8 and 14, rats were administered AMPH or saline. In both experiments, locomotor activity was measured using the open-field test and BDNF levels were measured in rat hippocampus by sandwich-ELISA. Li and VPT reversed AMPH-induced behavioral effects in the open-field test in both experiments. In the first experiment, Li increased BDNF levels in rat hippocampus. In the second experiment, AMPH decreased BDNF levels and Li and VPT increased BDNF levels in rat hippocampus. Our results suggest that the present model fulfills adequate face, construct and predictive validity as an animal model of mania. (c) 2006 Elsevier Inc. All rights reserved.