HUMAN-BREAST CANCER AND IMPAIRED NK-CELL FUNCTION
HUMAN-BREAST CANCER AND IMPAIRED NK-CELL FUNCTION
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DOI：
10.1002/jso.2930240115
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发表时间：
1983-01-01
影响因子：
2.5
通讯作者：
HOFFMANN, CC
中科院分区：
文献类型：
--
作者：
GARNER, WL;MINTON, JP;HOFFMANN, CC
自然杀伤 (NK) 细胞形成抗肿瘤监视系统，似乎对于预防肿瘤生长和转移至关重要。使用以 K562 细胞为靶标的 51 铬释放微量滴定细胞毒性测定法，研究了良性和恶性乳腺疾病患者的 NK 活性。与良性对照相比，恶性肿瘤患者的 NK 介导的裂解显着降低（P < 0.01）。此外，晚期疾病患者（II、III 和 IV 期）的裂解明显少于局限性疾病患者（I 期）（P < 0.01）。 NK 活性与雌激素或孕激素受体状态无关。自然杀伤活性降低与肿瘤扩散程度呈正相关，支持了乳腺癌中 NK 细胞免疫监视系统的概念，并强调了其在这种恶性肿瘤中的重要性。
Natural killer (NK) cells form an antitumor surveillance system and appear to be vital in preventing tumor growth and metastasis. NK activity was studied in patients with benign and malignant breast disease, using a chromium-51 release microtiter cytotoxicity assay with K562 cells as targets. Compared with benign controls, patients with malignancies had significantly depressed NK-mediated lysis (P < 0.01). Furthermore, lysis in those with advanced disease (stages II, III, and IV) was significantly less than in those with limited disease (stage I) (P < 0.01). NK activity was not correlated to estrogen or progesterone receptor states. Positive correlation of a depressed natural killer activity with the extent of tumor spread supports the concept of an NK cell immune surveillance system in breast cancer and emphasizes its importance in this malignancy.