Hyperthermia and low dose-rate irradiation.
Hyperthermia and low dose-rate irradiation.
复制标题
高热和低剂量率照射。
作者：
L. Harisiadis;D. I. Sung;N. Kessaris;E. Hall
以体外培养的V79仓鼠细胞为研究对象，研究了高温联合60Coγ射线照射对V79细胞的影响。轻度高热(41摄氏度，持续6小时)增强了因急性辐射而产生的细胞杀伤力。同样的处理增强了低剂量率照射(200rads/hr)的效果。甚至更多。适度热疗与低剂量率照射相结合的顺序很重要。当热疗后再进行照射时，增强效果最好。可能的解释是，通过破坏修复系统，先前的热量使细胞无法在随后的低剂量率照射期间修复亚致死损伤。
Hyperthermia combined with 60Co gamma irradiation was studied using V79 hamster cells cultured in vitro. Modest hyperthermia (41 degrees C for 6 hrs.) enhanced the cell killing produced by acute exposure to radiation. The same treatment enhanced the effect of low dose-rate irradiation (200 rads/hr.) even more. The sequence in which modest hyperthermia was combined with low dose-rate irradiation was important. Maximal enhancement was observed when hyperthermia was followed by irradiations. The probable explanation is that, by damaging the repair system, prior heat renders the cells unable to repair sublethal damage during subsequent low dose-rate irradiation.