Born with low birth weight in rural Southern India: what are the metabolic consequences 20 years later?
Born with low birth weight in rural Southern India: what are the metabolic consequences 20 years later?
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DOI：
10.1530/eje-11-0870
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发表时间：
2012-04-01
影响因子：
5.8
通讯作者：
Bygbjerg, Ib C.
中科院分区：
文献类型：
--
作者：
Thomas, Nihal;Grunnet, Louise G.;Bygbjerg, Ib C.
目的：低出生体重（LBW）在印度人群中很常见，可能是2型糖尿病（T2D）和代谢综合征的重要易感因素。密集的代谢检查，在种族LBW亚洲印度人几乎完全是在印度以外的移民生活。因此，我们的目的是研究出生低出生体重在农村非移民Indian population.Subjects和方法的代谢影响：一百一十七个非移民，年轻健康的男性被招募从出生队列在印度南部的农村地区。受试者包括61名LBW和56名正常出生体重（NBW）男性，NBW男性作为对照。受试者接受了高胰岛素正常血钳夹、静脉注射和口服葡萄糖耐量试验以及双能X线吸收扫描。结果：低出生体重组男性身高较低（167 ± 6.4cm vs 172 ± 6.0cm，P
Objective: Low birth weight (LBW) is common in the Indian population and may represent an important predisposing factor for type 2 diabetes (T2D) and the metabolic syndrome. Intensive metabolic examinations in ethnic LBW Asian Indians have been almost exclusively performed in immigrants living outside India. Therefore, we aimed to study the metabolic impact of being born with LBW in a rural non-migrant Indian population.Subjects and methods: One hundred and seventeen non-migrant, young healthy men were recruited from a birth cohort in a rural part of south India. The subjects comprised 61 LBW and 56 normal birth weight (NBW) men, with NBW men acting as controls. Subjects underwent a hyperinsulinaemic euglycaemic clamp, i.v. and oral glucose tolerance tests and a dual-energy X-ray absorptiometry scan. The parents' anthropometric status and metabolic parameters were assessed.Results: Men with LBW were shorter (167 +/- 6.4 vs 172 +/- 6.0 cm, P