Mechanism linking diabetes mellitus and obesity.
Mechanism linking diabetes mellitus and obesity.
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DOI：
10.2147/dmso.s67400
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Khan MZ
中科院分区：
文献类型：
--
作者：
Al-Goblan AS;Al-Alfi MA;Khan MZ
身体质量指数与糖尿病和胰岛素抵抗有很强的关系。在肥胖个体中，非酯化脂肪酸、甘油、激素、细胞因子、促炎标志物和其他与胰岛素抵抗有关的物质的数量增加。糖尿病的发病机制是基于胰腺β-胰岛细胞受损，导致血糖缺乏控制。如果胰腺β-胰岛细胞的衰竭伴有胰岛素抵抗，糖尿病的发展就更加不可避免。体重增加和体重增加是1型和2型糖尿病形成和发病率上升的主要原因。这篇文献综述将证明肥胖与胰岛素抵抗和胰腺β细胞功能障碍之间的联系。总之，管理和预防肥胖个体糖尿病的新方法必须根据事实进行研究和调查。
Body mass index has a strong relationship to diabetes and insulin resistance. In obese individuals, the amount of nonesterified fatty acids, glycerol, hormones, cytokines, proinflammatory markers, and other substances that are involved in the development of insulin resistance, is increased. The pathogenesis in the development of diabetes is based on the fact that the β-islet cells of the pancreas are impaired, causing a lack of control of blood glucose. The development of diabetes becomes more inevitable if the failure of β-islet cells of the pancreas is accompanied by insulin resistance. Weight gain and body mass are central to the formation and rising incidence of type 1 and type 2 diabetes. This literature review will demonstrate the facts that link obesity with insulin resistance and pancreatic β-cell dysfunction. In conclusion, new approaches in managing and preventing diabetes in obese individuals must be studied and investigated based on the facts.