The changing Brucella ecology: novel reservoirs, new threats
The changing Brucella ecology: novel reservoirs, new threats
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DOI：
10.1016/j.ijantimicag.2010.06.013
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发表时间：
2010-11-01
影响因子：
10.8
通讯作者：
Pappas, Georgios
中科院分区：
文献类型：
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作者：
Pappas, Georgios
布鲁氏菌病是一种先于人类的人畜共患病，但继续造成重大的医疗、兽医和社会经济问题，主要是因为其总体负担仍然被低估和忽视。它的生态学，或者说我们所知道的生态学，近年来发展迅速。2个新种，即鲸布氏杆菌（Brucella ceti）和B.从海洋哺乳动物中分离出了可能引起人类疾病的pinnipedialis。另一个新种是B. microti，已从野生动物中分离到，而B.已从一个人类病例中分离出inopinata。布鲁氏菌在家畜和野生动物之间的积极溢出也被认识到，麋鹿传播B。牛流产，淡水鱼感染B。废肉中的梅利滕斯。近年来，除了撒哈拉以南非洲地区对布鲁氏菌病的认识有所提高以及巴尔干半岛的半岛的疾病流行迅速扩大外，该疾病的全球流行病学没有发生重大变化。孤立的故事和事件强调布鲁氏菌不分国界。现代世界为病原体提供了在任何地方旅行和表现自己的能力，也为科学家提供了比以往任何时候都更好地跟踪这些表现的能力。这可能使疾病不再被忽视，或者至少被认为是被忽视的。(C)2010年Elsevier B.V.和国际化疗学会。All rights reserved.
Brucellosis is a zoonosis that preceded humans but continues to cause significant medical, veterinary and socioeconomic problems, mainly because its overall burden remains underestimated and neglected. Its ecology, or what we know of it, has evolved rapidly in recent years. Two novel species, Brucella ceti and B. pinnipedialis, with the potential for causing human disease have been isolated from marine mammals. Another novel species, B. microti, has been isolated from wildlife animals, whilst B. inopinata has been isolated from a human case. An active spillover of Brucella between domestic animals and wildlife is also being recognised, with elk transmitting B. abortus to cattle, and freshwater fish becoming infected with B. melitensis from waste meat. In recent years the global epidemiology of the disease has not altered drastically, apart from increased awareness of brucellosis in sub-Saharan Africa and a rapid expansion of disease endemicity in the Balkan Peninsula. Isolated stories and events underline that Brucella knows no borders. The modern world has offered the pathogen the ability to travel and manifest itself anywhere and has also offered scientists the ability to track these manifestations better than ever before. This may allow the disease to be neglected no longer, or at least to be recognised as neglected. (C) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.