Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions
Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions
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DOI：
10.1038/nn.2126
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发表时间：
2008-06-01
影响因子：
25
通讯作者：
Kawata, Mitsuhiro
中科院分区：
文献类型：
--
作者：
Sakamoto, Hirotaka;Matsuda, Ken-Ichi;Kawata, Mitsuhiro
上腰椎脊髓中的神经元投射含有胃泌素释放肽（GRP）的轴突，以支配下腰椎区域，控制勃起和射精。该系统在雌性大鼠和雄激素受体遗传功能障碍的雄性大鼠中是残留的，但在雄性大鼠中，脊髓GRP受体的药理学刺激恢复了去势后的阴茎反射和射精。GRP为了解男性生殖功能障碍的潜在治疗方法提供了新的途径。
Neurons in the upper lumbar spinal cord project axons containing gastrin-releasing peptide (GRP) to innervate lower lumbar regions controlling erection and ejaculation. This system is vestigial in female rats and in males with genetic dysfunction of androgen receptors, but in male rats, pharmacological stimulation of spinal GRP receptors restores penile reflexes and ejaculation after castration. GRP offers new avenues for understanding potential therapeutic approaches to masculine reproductive dysfunction.