Glycopeptide-functionalized gold nanoparticles for antibody induction against the tumor associated mucin-1 glycoprotein
Glycopeptide-functionalized gold nanoparticles for antibody induction against the tumor associated mucin-1 glycoprotein
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DOI：
10.1016/j.bmc.2016.01.044
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发表时间：
2016-03-01
影响因子：
3.5
通讯作者：
Westerlind, Ulrika
中科院分区：
文献类型：
--
作者：
Cai, Hui;Degliangeli, Federica;Westerlind, Ulrika
我们报告了制备基于金纳米颗粒（AuNP）的候选疫苗，以对抗肿瘤相关形式的粘蛋白-1（MUC 1）糖蛋白。嵌合肽，由来自MUC 1和T细胞表位P30序列的糖肽序列组成的固定在PEG化的金纳米颗粒和在体内诱导选择性抗体的能力进行了研究。免疫后，小鼠表现出显着的MHC-II介导的免疫应答，其抗血清识别人MCF-7乳腺癌细胞。根据该报告设计的纳米颗粒可能成为抗癌疫苗开发的关键参与者。(C)2016爱思唯尔有限公司版权所有
We report the preparation of gold nanoparticle (AuNP)-based vaccine candidates against the tumor-associated form of the mucin-1 (MUC1) glycoprotein. Chimeric peptides, consisting of a glycopeptide sequence derived from MUC1 and the T-cell epitope P30 sequence were immobilized on PEGylated AuNPs and the ability to induce selective antibodies in vivo was investigated. After immunization, mice showed significant MHC-II mediated immune responses and their antisera recognized human MCF-7 breast cancer cells. Nanoparticles designed according to this report may become key players in the development of anticancer vaccines. (C) 2016 Elsevier Ltd. All rights reserved.