Dimensions of sedentary behavior and objective cognitive functioning in breast cancer survivors.
Dimensions of sedentary behavior and objective cognitive functioning in breast cancer survivors.
复制标题
乳腺癌幸存者久坐行为和客观认知功能的维度。
DOI：
10.1007/s00520-018-4459-8
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Hartman,SheriJ
中科院分区：
文献类型：
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作者：
Marinac,CatherineR;Nelson,SandahlH;Cadmus-Bertram,Lisa;Kerr,Jacqueline;Natarajan,Loki;Godbole,Suneeta;Hartman,SheriJ
PurposeTo研究乳腺癌survivor.MethodsSedentary行为变量的久坐行为和认知功能的尺寸之间的关联进行了测量，使用大腿佩戴activPAL，包括总的日常坐着的时间，在长时间坐着的时间，坐到站的过渡，和站立的时间。认知功能使用NIH认知领域评估。单独的多变量线性回归模型被用来研究久坐不动的行为变量与认知领域的注意力，执行功能，情景记忆，工作记忆，和信息处理speed.ResultsThirty乳腺癌幸存者的平均年龄为62.2（SD = 7.8）年，2.6（SD = 1.1）年，因为诊断完成了研究评估的分数之间的关联。在多变量线性回归模型中，校正协变量后，站立时间越长，信息处理速度越快（B：5.78;p= 0.03），久坐时间越长，执行功能越差（B：-2.82;p= 0.02）。没有其他久坐不动的行为变量在统计学上显着相关的认知域检查在本study.ConclusionsTwo重要的久坐结构，适合干预，包括时间在长时间坐着发作和站立的时间，可能与乳腺癌幸存者的认知功能。需要更多的研究来确定改变久坐行为的这些方面是否会改善有乳腺癌病史的女性的认知功能，或者防止乳腺癌患者的认知功能下降。
PurposeTo examine associations between dimensions of sedentary behavior and cognitive function in breast cancer survivors.MethodsSedentary behavior variables were measured using thigh-worn activPALs, and included total daily sitting time, time in long sitting bouts, sit-to-stand transitions, and standing time. Cognitive function was assessed using the NIH Toolbox Cognitive Domain. Separate multivariable linear regression models were used to examine associations between sedentary behavior variables with the cognitive domain scores of attention, executive functioning, episodic memory, working memory, and information processing speed.ResultsThirty breast cancer survivors with a mean age of 62.2 (SD = 7.8) years who were 2.6 (SD = 1.1) years since diagnosis completed study assessments. In multivariable linear regression models, more time spent standing was associated with faster information processing (b: 5.78;p= 0.03), and more time spent in long sitting bouts was associated with worse executive function (b: −2.82;p= 0.02), after adjustment for covariates. No other sedentary behavior variables were statistically significantly associated with the cognitive domains examined in this study.ConclusionsTwo important sedentary constructs that are amenable to intervention, including time in prolonged sitting bouts and standing time, may be associated with cognitive function in breast cancer survivors. More research is needed to determine whether modifying these dimensions of sedentary behavior will improve cognitive function in women with a history of breast cancer, or prevent it from declining in breast cancer patients.