Microsecond-Scale Timing Precision in Rodent Trigeminal Primary Afferents
Microsecond-Scale Timing Precision in Rodent Trigeminal Primary Afferents
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DOI：
10.1523/jneurosci.3876-14.2015
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发表时间：
2015-04-15
影响因子：
5.3
通讯作者：
Petersen, Rasmus S.
中科院分区：
文献类型：
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作者：
Bale, Michael R.;Campagner, Dario;Petersen, Rasmus S.
神经系统中的通信通过尖峰信号发生：尖峰信号发射的时间精度是神经信息处理的基本限制。在感觉系统中，尖峰定时精度受到一阶神经元的限制。我们发现，在大鼠和小鼠三叉神经初级传入的尖峰定时精度是有限的刺激速度和电生理采样率。行为小鼠的高速视频显示胡须速度至少为17，000度/秒，因此我们向单个胡须发送超快“ping”（> 50，000度/秒），并以500 kHz采样初级传入活动。中位锋电位抖动为17.4 μ s; 29%的神经元有锋电位抖动
Communication in the nervous system occurs by spikes: the timing precision with which spikes are fired is a fundamental limit on neural information processing. In sensory systems, spike-timing precision is constrained by first-order neurons. We found that spike-timing precision of trigeminal primary afferents in rats and mice is limited both by stimulus speed and by electrophysiological sampling rate. High-speed video of behaving mice revealed whisker velocities of at least 17,000 degrees/s, so we delivered an ultrafast "ping" (>50,000 degrees/s) to single whiskers and sampled primary afferent activity at 500 kHz. Median spike jitter was 17.4 mu s; 29% of neurons had spike jitter