Nanocolloidal Hydrogel with Sensing and Antibacterial Activities Governed by Iron Ion Sequestration
Nanocolloidal Hydrogel with Sensing and Antibacterial Activities Governed by Iron Ion Sequestration
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DOI：
10.1021/acs.chemmater.0c03362
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发表时间：
2020-12-08
影响因子：
8.6
通讯作者：
Kumacheva, Eugenia
中科院分区：
文献类型：
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作者：
Chekini, Mahshid;Krivoshapkina, Elena;Kumacheva, Eugenia
先进的伤口敷料通过释放抗菌剂、加速伤口闭合和报告（感测）伤口状态的变化来改善伤口愈合。释放抗菌剂如药物、肽或纳米颗粒的挑战是它们的不受管制的施用。此外，细菌对抗生素的耐药性刺激了对新型抗菌伤口敷料的研究。在这里，我们报告了一种新的抗菌伤口敷料的方法，利用具有强大的Fe 3+离子螯合能力的纳米胶体水凝胶，从而剥夺了细菌急需的离子铁，抑制细菌生长。该水凝胶衍生自用碳量子点（C-dot/CNCs）修饰的纤维素纳米晶体。在Fe 3+离子被纳米纤维状水凝胶吸收后，由于离子吸附到C点表面，水凝胶的光致发光被淬灭，因此报告了离子铁从介质中的去除。该水凝胶抑制耐药革兰氏阴性大肠杆菌、耐药铜绿假单胞菌和革兰氏阳性金黄色葡萄球菌的生长，对人成纤维细胞无细胞毒性。伤口敷料易于使用三维（3D）打印制造。水凝胶抗菌性能的新机制，其传感能力，生物相容性以及3D打印伤口敷料贴片的能力使其成为制造先进伤口敷料的非常有前途的材料。
Advanced wound dressings improve wound healing by releasing antibacterial agents, accelerating wound closure, and reporting (sensing) changes in the wound's state. The challenge with the release of antibacterial agents such as drugs, peptides, or nanoparticles is their unregulated administration. In addition, bacteria resistance to antibiotics stimulates the search for new types of antibacterial wound dressings. Here, we report a new approach to antibacterial wound dressings by utilizing a nanocolloidal hydrogel with strong Fe3+ ion sequestration capability, thus depriving bacteria of much-needed ionic iron and suppressing bacteria growth. The hydrogel was derived from cellulose nanocrystals decorated with carbon dots (C-dot/CNCs). Upon Fe3+ ion uptake by the nanofibrillar hydrogel, the photoluminescence of the hydrogel was quenched, due to adsorption of ions to the C-dot surface, thus reporting on the removal of ionic iron from the medium. The hydrogel suppressed the growth of antibiotic-resistant Gram-negative Escherichia coli, antibiotic-resistant Pseudomonas aeruginosa, and Gram-positive Staphylococcus aureus and was noncytotoxic for human fibroblasts. Wound dressings were readily fabricated using three-dimensional (3D) printing. The new mechanism of antibacterial performance of the hydrogel, its sensing capability, biocompatibility, and the capability to 3D print wound dressing patches make it a very promising material for the fabrication of advanced wound dressings.