Characterization of activities of daily living in individuals with mild cognitive impairment
Characterization of activities of daily living in individuals with mild cognitive impairment
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DOI：
10.1097/jgp.0b013e318162f197
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发表时间：
2008-05-01
影响因子：
7.2
通讯作者：
Karlawish, Jason H.
中科院分区：
文献类型：
--
作者：
Jefferson, Angela L.;Byerly, Laura K.;Karlawish, Jason H.
目的：确定轻度认知障碍 (MCI) 参与者与认知正常 (NC) 老年人在传统和新颖的基于知情者的日常生活活动 (ADL) 测量方面是否存在差异，并确定 MCI 参与者中 ADL 的认知相关性。设计：横截面。环境：大学医疗环境。参与者：77 名参与者（NC：N = 39；MCI：N = 38），年龄 60 至 90 岁（73.5 +/- 6.6 岁；53% 女性）。测量：神经心理学和 ADL 测量。方法：对 NC 和 MCI 参与者进行神经心理学测试。受访者完成了劳顿和布罗迪工具性日常生活活动和身体自我维护量表，包括工具性（IADL）和基本ADL（BADL）量表，以及日常生活活动功能能力（FC-ADL），这是一种基于错误的ADL测量方法。结果：BADL 或 IADL 分量表没有出现统计学或临床显着的组间差异。然而，FC-ADL 量表存在显着差异（MCI 误差 > NC 误差；F-(1,F-75) = 13.6，p < 0.001；d = 0.84）。在 MCI 参与者中，相关性显示言语学习测量是 FC-ADL 总分的唯一神经心理学相关性（r= - 0.39，df = 36，p = 0.007）。没有神经心理学测量与 IADL 或 BADL 子量表评分显着相关。结论：评估总体 ADL 的传统方法可能对 MCI 相关的早期功能变化不敏感；然而，基于误差的测量可能会捕捉到与 MCI 相关的微妙的、不断变化的功能衰退。在 MCI 参与者中，早期功能困难与言语学习表现相关，可能继发于与该群体相关的标志性认知障碍。
Objective: To determine whether participants with mild cognitive impairment ( MCI) differ from cognitively normal ( NC) older adults on traditional and novel informant-based measures of activities of daily living ( ADL) and to identify cognitive correlates of ADLs among participants with MCI. Design: Cross-sectional. Setting: University medical setting. Participants: Seventy-seven participants ( NC: N = 39; MCI: N = 38), 60 to 90 years old ( 73.5 +/- 6.6 years; 53% female). Measurements: Neuropsychological and ADL measures. Methods: Neuropsychological tests were administered to NC and MCI participants. Informants completed the Lawton and Brody Instrumental Activities of Daily Living and Physical Self-Maintenance Scale, including instrumental ( IADL) and basic ADL ( BADL) scales, as well as the Functional Capacities for Activities of Daily Living ( FC-ADL), an error-based ADL measure. Results: No statistically or clinically significant between-group differences emerged for the BADL or IADL subscales. However, a robust difference was noted for the FC-ADL scale ( MCI errors > NC errors; F-(1,F-75) = 13.6, p < 0.001; d = 0.84). Among MCI participants, correlations revealed that a measure of verbal learning was the only neuropsychological correlate of FC- ADL total score ( r= - 0.39, df = 36, p = 0.007). No neuropsychological measures were significantly associated with the IADL or BADL subscale score. Conclusion: Traditional measures assessing global ADLs may not be sensitive to early functional changes related to MCI; however, error-based measures may capture the subtle evolving functional decline associated with MCI. Among MCI participants, early functional difficulties are associated with verbal learning performance, possibly secondary to the hallmark cognitive impairment associated with this cohort.