The sequence of formation and development of corticostriate connections in mice.
The sequence of formation and development of corticostriate connections in mice.
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小鼠皮质纹状连接的形成和发育顺序。
DOI：
10.1159/000017306
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发表时间：
1998
影响因子：
2.9
通讯作者：
Bhide,PG
中科院分区：
文献类型：
--
作者：
Sheth,AN;McKee,ML;Bhide,PG
我们用碳菁染料1，1 ′-双十八烷基-3，3，3 ′-3′-四甲基吲哚碳菁高氯酸盐（DiI）标记小鼠离皮质轴突，研究了小鼠皮质纹状体通路的发育。离皮质轴突的生长锥在胚胎第12天（E12;受孕是在E0）进入发育中的纹状体。到E15，离皮质轴突穿过内囊中发育中的纹状体，但不产生纹状体侧支。在E18，即最早到达的轴突进入纹状体后6天，第一次看到皮质纹状体侧支。此时，皮质轴突和纹状体神经元之间形成假定的突触接触。皮质纹侧支起源于轴突静脉曲张处或附近的离皮质轴突干。原始皮质纹状体乔木形成出生后第2天（P2;出生日为P0），并进一步发展的P7。因此，皮质纹状体连接的发展在三个形态学定义的阶段：第一皮质轴突延长通过纹状体到其他皮质下的目标，其次，他们产生纹状体侧支，最后，他们阐述终端乔木。从延伸到侧支化阶段的过渡可能是由来自纹状体神经元的经由突触接触传递的信号触发的。
We examined the development of the corticostriate pathway in mice by labeling corticofugal axons with the carbocyanine dye 1,1′-dioctadecyl-3,3,3′-3′-tetramethylindocarbocyanine perchlorate (DiI). Growth cones of corticofugal axons enter the developing striatum on embryonic day 12 (E12; conception is on E0). By E15 corticofugal axons pass through the developing striatum in the internal capsule but do not produce striatal collaterals. Corticostriate collaterals are seen for the first time on E18, 6 days after the earliest arriving axons enter the striatum. At that time, presumptive synaptic contacts form between cortical axons and striatal neurons. Corticostriate collaterals arise from corticofugal axon trunks at or near axonal varicosities. Primitive corticostriate arbors form by postnatal day 2 (P2; day of birth is P0) and develop further by P7. Thus, corticostriate connections develop in three morphologically defined stages: first cortical axons elongate through the striatum to other subcortical targets, next they produce striatal collaterals, and finally they elaborate terminal arbors. The transition from elongation to collateralization stage may be triggered, among other factors, by signals from striatal neurons relayed via the synaptic contacts.