Respiratory lesions in IgG4-related disease: classification using 2019 American College of Rheumatology/European League Against Rheumatism criteria
Respiratory lesions in IgG4-related disease: classification using 2019 American College of Rheumatology/European League Against Rheumatism criteria
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DOI：
10.1183/23120541.00120-2022
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发表时间：
2022-07
影响因子：
4.6
通讯作者：
M. Komatsu;Hiroshi Yamamoto;Shoko Matsui;Y. Terasaki;A. Hebisawa;T. Iwasawa;T. Johkoh;T. Baba;A. Miyamoto;T. Handa;K. Tomii;Y. Waseda;M. Bando;H. Ishii;Y. Miyazaki;A. Yoshizawa;T. Takemura;Y. Kawabata;M. Hanaoka;T. Ogura
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作者：
M. Komatsu;Hiroshi Yamamoto;Shoko Matsui;Y. Terasaki;A. Hebisawa;T. Iwasawa;T. Johkoh;T. Baba;A. Miyamoto;T. Handa;K. Tomii;Y. Waseda;M. Bando;H. Ishii;Y. Miyazaki;A. Yoshizawa;T. Takemura;Y. Kawabata;M. Hanaoka;T. Ogura
2019年，美国风湿病学会(ACR)和欧洲抗风湿病联盟(EULAR)提出了IgG4相关疾病(IgG4-RD)的分类标准[1，2]。IgG4-RD可导致纤维炎症损害，其特征是大量IgG4阳性浆细胞的浸润和纤维化以及血清IgG4浓度升高[3-5]。大约35%的IgG4-RD患者存在胸腔内病变，包括累及纵隔淋巴结、支气管壁和支气管血管周围束的病变[6-8]。为了提高诊断的敏感性和特异性，我们先前提出了IgG4相关呼吸道疾病(IgG4-RRD)的诊断标准[9]。在本研究中，根据2019年ACR/EULAR标准对涉及IgG4阳性浆细胞浸润的ILDS进行了分类。大多数IgG4阳性的间质性肺炎病例被排除在外，这表明需要一种独特的治疗策略。Https://bit.ly/38GiUJM
In 2019, the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) proposed classification criteria for IgG4-related disease (IgG4-RD) [1,2]. IgG4-RD can cause fibroinflammatory lesions characterised by infiltration of abundant IgG4-positive plasma cells with fibrosis and an elevated serum IgG4 concentration [3–5]. Approximately 35% of patients with IgG4-RD present with intrathoracic lesions, including those involving the mediastinal lymph nodes, bronchial walls and peribronchovascular bundles [6–8]. To increase diagnostic sensitivity and specificity, we previously proposed diagnostic criteria for IgG4-related respiratory disease (IgG4-RRD) [9]. In this study, ILDs involving IgG4-positive plasma cell infiltration were classified using the 2019 ACR/EULAR criteria. Most IgG4-positive interstitial pneumonia cases were excluded, suggesting the need for a unique treatment strategy. https://bit.ly/38GiUJM