Accuracy and agreement of PIRADSv2 for prostate cancer mpMRI: A multireader study.
Accuracy and agreement of PIRADSv2 for prostate cancer mpMRI: A multireader study.
复制标题
DOI：
10.1002/jmri.25372
复制
发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Turkbey B
中科院分区：
文献类型：
--
作者：
Greer MD;Brown AM;Shih JH;Summers RM;Marko J;Law YM;Sankineni S;George AK;Merino MJ;Pinto PA;Choyke PL;Turkbey B
多参数MRI（mpMRI）可提高临床显著前列腺癌的检出率，但受观察者间差异的限制。前列腺成像报告和数据系统（PIRADSv2）的第二个版本最近被提议作为解释mpMRI的标准。为了评估PIRADSv2的性能和观察者间一致性，我们与5名经验不同的放射科医生进行了一项多读者研究。5名放射科医生（n = 2名前列腺专用，n = 3名全身）对使用PIRADSv2在前列腺mpMRI上检测和评分病变的临床病理结果设盲。直肠内线圈3 T MRI包括T2W、扩散加权成像（表观扩散系数，b2000）和动态对比增强。纳入了34例连续患者。结果与根治性前列腺切除术整体组织病理学与患者特异性三维模具。根据病理学将索引病变定义为具有最高Gleason评分或最大体积（如果分级相同）的病变。使用广义估计方程确定所有病变和指数病变的平均敏感性和阳性预测值（PPV）。观察者间的一致性采用特异性一致性指数进行评价。所有阅片者检测索引病变的平均灵敏度为91%，检测所有病变的平均灵敏度为63%。PIRADS ≥ 3的PPV为85%，PIRADS ≥ 4的PPV为90%。专科医生仅在PIRADS ≥ 4时表现更好，敏感性为90%，而索引病变为79%（P = 0.01）。阅片者之间的特异性一致性指数分别为：指示病变检出率为93%，所有病变检出率为74%，指示病变评分率为85%，所有病变评分率为58%。通过使用PIRADSv2，一般身体放射科医生和前列腺专家可以以高灵敏度和一致性检测高级别指数前列腺癌病变。1
Multiparametric MRI (mpMRI) improves the detection of clinically significant prostate cancer, but is limited by interobserver variation. The second version of theProstate Imaging Reporting and Data System (PIRADSv2) was recently proposed as a standard for interpreting mpMRI. To assess the performance and interobserver agreement of PIRADSv2 we performed a multi-reader study with five radiologists of varying experience. Five radiologists (n = 2 prostate dedicated, n = 3 general body) blinded to clinicopathologic results detected and scored lesions on prostate mpMRI using PIRADSv2. The endorectal coil 3 Tesla MRI included T2W, diffusion-weighted imaging (apparent diffusion coefficient, b2000), and dynamic contrast enhancement. Thirty-four consecutive patients were included. Results were correlated with radical prostatectomy whole-mount histopathology produced with patient-specific three-dimensional molds. An index lesion was defined on pathology as the lesion with highest Gleason score or largest volume if equivalent grades. Average sensitivity and positive predictive values (PPVs) for all lesions and index lesions were determined using generalized estimating equations. Interobserver agreement was evaluated using index of specific agreement. Average sensitivity was 91% for detecting index lesions and 63% for all lesions across all readers. PPV was 85% for PIRADS ≥ 3 and 90% for PIRADS ≥ 4. Specialists performed better only for PIRADS ≥ 4 with sensitivity 90% versus 79% (P = 0.01) for index lesions. Index of specific agreement among readers was 93% for the detection of index lesions, 74% for the detection of all lesions, and 85% for scoring index lesions, and 58% for scoring all lesions. By using PIRADSv2, general body radiologists and prostate specialists can detect high-grade index prostate cancer lesions with high sensitivity and agreement. 1
登录
查看更多内容
影响因子：
2.6
作者：
Miyagawa, Tomoaki;Ishikawa, Satoru;Mitake, Tsuyoshi
通讯作者：
Mitake, Tsuyoshi
MR/超声融合引导的活检与超声引导活检的比较，以诊断前列腺癌。
DOI：
10.1001/jama.2014.17942
发表时间：
2015-01-27
期刊：
JAMA
影响因子：
--
作者：
Siddiqui MM;Rais-Bahrami S;Turkbey B;George AK;Rothwax J;Shakir N;Okoro C;Raskolnikov D;Parnes HL;Linehan WM;Merino MJ;Simon RM;Choyke PL;Wood BJ;Pinto PA
通讯作者：
Pinto PA
影响因子：
23.4
作者：
Siddiqui MM;Rais-Bahrami S;Truong H;Stamatakis L;Vourganti S;Nix J;Hoang AN;Walton-Diaz A;Shuch B;Weintraub M;Kruecker J;Amalou H;Turkbey B;Merino MJ;Choyke PL;Wood BJ;Pinto PA
通讯作者：
Pinto PA
DOI：
10.1016/j.juro.2011.05.078
发表时间：
2011-10
期刊：
The Journal of urology
影响因子：
--
作者：
Pinto PA;Chung PH;Rastinehad AR;Baccala AA Jr;Kruecker J;Benjamin CJ;Xu S;Yan P;Kadoury S;Chua C;Locklin JK;Turkbey B;Shih JH;Gates SP;Buckner C;Bratslavsky G;Linehan WM;Glossop ND;Choyke PL;Wood BJ
通讯作者：
Wood BJ
影响因子：
7.2
作者：
FEINSTEIN, AR;CICCHETTI, DV
通讯作者：
CICCHETTI, DV