Plant-like traits associated with metabolism of Trypanosoma parasites
Plant-like traits associated with metabolism of Trypanosoma parasites
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DOI：
10.1073/pnas.0335769100
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发表时间：
2003-02-04
影响因子：
11.1
通讯作者：
Opperdoes, FR
中科院分区：
文献类型：
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作者：
Hannaert, V;Saavedra, E;Opperdoes, FR
锥虫寄生虫在人类、牲畜和植物中引起严重疾病。它们属于动质体目，并与眼虫目一起形成眼虫门。裸藻具有能够进行光合作用的质体，但在锥虫中质体是未知的。在这里，我们提出的分子证据，锥虫拥有一个质体在某些时候在他们的进化历史。现存的锥虫寄生虫，如锥虫属和利什曼原虫，含有几个“植物样”基因，编码植物和藻类叶绿体或细胞质中发现的蛋白质同源物。这些数据表明，动质体和裸藻获得质体的内共生之前，他们的分歧和前血统随后失去了细胞器，但保留了许多基因。这些基因编码的几种蛋白质现在在寄生虫中被发现存在于高度特化的过氧化物酶体（称为糖体）中，而在包括裸藻在内的所有其他真核生物中都没有。
Trypanosomatid parasites cause serious diseases among humans, livestock, and plants. They belong to the order of the Kinetoplastida and form, together with the Euglenida, the phylum Eugleno-zoa. Euglenoid algae possess plastids capable of photosynthesis, but plastids are unknown in trypanosomatids. Here we present molecular evidence that trypanosomatids possessed a plastid at some point in their evolutionary history. Extant trypanosomatid parasites, such as Trypanosoma and Leishmania, contain several "plant-like" genes encoding homologs of proteins found in either chloroplasts or the cytosol of plants and algae. The data suggest that kinetoplastids and euglenoids acquired plastids by endosymbiosis before their divergence and that the former lineage subsequently lost the organelle but retained numerous genes. Several of the proteins encoded by these genes are now, in the parasites, found inside highly specialized peroxisomes, called glycosomes, absent from all other eukaryotes, including euglenoids.