Regional Patterns of Cerebral Cortical Differentiation Determined by Diffusion Tensor MRI
Regional Patterns of Cerebral Cortical Differentiation Determined by Diffusion Tensor MRI
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DOI：
10.1093/cercor/bhp061
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发表时间：
2009-12-01
期刊：
影响因子：
3.7
通讯作者：
Bayly, Philip V.
中科院分区：
文献类型：
--
作者：
Kroenke, Christopher D.;Taber, Erin N.;Bayly, Philip V.
未成熟大脑皮层中轴突和树突的形态影响水扩散的各向异性程度。这使得皮质的成熟可以通过扩散张量磁共振成像（DTI）的非侵入性技术进行监测。在此，我们利用死后白鼬脑的DTI来量化皮质成熟的区域和时间模式。我们发现，扩散各向异性内的isocortex减少了第一个月的生活，在时间上与锥体神经元的轴突和树突状细胞的过程的扩展密切一致。区域模式包括allocortex和isocortex之间的差异，区域各向异性梯度，密切平行的横向神经发生梯度，和原发性和非原发性isocortex区域之间的差异。通过结合时间和区域因素，等皮质发育梯度幅度对应于5天的差异，在梯度源和不太成熟的等皮质在枕极相对发达的吻/尾等皮质之间的成熟度。此外，主要区域的发育轨迹比非主要区域早2.7天。这些定量估计与以前的雪貂发育的组织学研究相吻合。雪貂和其他物种之间观察到的大脑皮层扩散各向异性的相似性表明，这里开发的框架是一般的潜在相关性。
The morphology of axonal and dendritic arbors in the immature cerebral cortex influences the degree of anisotropy in water diffusion. This enables cortical maturation to be monitored by the noninvasive technique of diffusion tensor magnetic resonance imaging (DTI). Herein, we utilized DTI of postmortem ferret brain to quantify regional and temporal patterns in cortical maturation. We found that diffusion anisotropy within the isocortex decreases over the first month of life, coinciding closely in time with expansion of axonal and dendritic cellular processes of pyramidal neurons. Regional patterns consist of differences between allocortex and isocortex, a regional anisotropy gradient that closely parallels the transverse neurogenetic gradient, and differences between primary and nonprimary isocortical areas. By combining the temporal and regional factors, the isocortical developmental gradient magnitude corresponds to a 5-day difference in maturity between relatively developed rostral/caudal isocortex at the gradient source and less mature isocortex at the occipital pole. Additionally, the developmental trajectory of primary areas precedes nonprimary areas by 2.7 days. These quantitative estimates coincide with previous histological studies of ferret development. Similarities in cerebral cortical diffusion anisotropy observed between ferret and other species suggest the framework developed here is of general potential relevance.