GASTRIC-MUCOSAL HISTAMINE AND HISTAMINE METHYLTRANSFERASE IN PATIENTS WITH DUODENAL-ULCER
GASTRIC-MUCOSAL HISTAMINE AND HISTAMINE METHYLTRANSFERASE IN PATIENTS WITH DUODENAL-ULCER
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DOI：
10.1136/gut.23.1.58
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发表时间：
1982-01-01
期刊：
影响因子：
24.5
通讯作者：
WORMSLEY, KG
中科院分区：
文献类型：
--
作者：
PEDEN, NR;CALLACHAN, H;WORMSLEY, KG
对110例十二指肠溃疡患者和62例正常对照的胃粘膜组织胺和组胺甲基转移酶(HMT)进行了检测。胃窦和胃底粘膜的HMT活性水平相似，尽管胃窦粘膜含有明显较少的组胺。十二指肠溃疡患者的胃底粘膜HMT活性和胃底粘膜组胺浓度均显著低于对照组。吸烟者的胃底粘膜组胺浓度显著低于不吸烟者(但不是HMT)，并且，由于十二指肠溃疡患者中吸烟者过多，这可能是这些患者胃底粘膜组胺浓度降低的原因。
Histamine and histamine methyltransferase (HMT) were measured in gastric mucosa from 110 patients with duodenal ulcer and 62 control subjects. Both antral and fundic mucosa had similar levels of HMT activity despite antral mucosa containing significantly less histamine. Patients with duodenal ulcer had significantly lower levels of fundic mucosal HMT activity and lower concentrations of fundic mucosal histamine than control subjects. Men who were cigarette smokers had significantly lower concentrations of fundic mucosal histamine (but not HMT) than nonsmokers and, as there was an excess of cigarette smokers among patients with duodenal ulcer, this may be the explanation for the reduced concentrations of fundic mucosal histamine in these patients.