Cancer chemotherapy-related symptoms: evidence to suggest a role for proinflammatory cytokines.
Cancer chemotherapy-related symptoms: evidence to suggest a role for proinflammatory cytokines.
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DOI：
10.1188/06.onf.535-542
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发表时间：
2006-05
影响因子：
1.9
通讯作者：
L. Wood;L. Nail;April Gilster;Kerri A Winters;Collin R. Elsea
中科院分区：
文献类型：
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作者：
L. Wood;L. Nail;April Gilster;Kerri A Winters;Collin R. Elsea
综述支持促炎细胞因子白细胞介素-1 β（IL-1 β）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）在癌症化疗相关症状病因学中作用的证据。资料来源电子护理，心理学和医学数据库，在线会议摘要和个人实验观察。资料综合大量证据表明促炎细胞因子IL-1 β、TNF-α和IL-6与化疗相关的厌食、恶病质、贫血、疼痛、睡眠障碍、疲劳和抑郁的病因有关。结论：进一步研究这些细胞因子在化疗相关症状发生中的作用是必要的。适当的动物模型的开发可能是理解癌症化疗，促炎细胞因子和症状之间关系的关键。传统上，护士一直是症状管理的领导者。接受化疗的患者所经历的症状对生活质量和患者接受处方治疗的能力具有深远的负面影响。了解化疗给药的生理和行为后果的潜在机制将有助于护士制定有效管理化疗相关症状的干预措施。
PURPOSE/OBJECTIVES To provide an overview of the evidence that supports a role for the proinflammatory cytokines interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in the etiology of cancer chemotherapy-related symptoms. DATA SOURCES Electronic nursing, psychology, and medicine databases; online meeting abstracts; and personal experimental observations. DATA SYNTHESIS Substantial evidence implicates the proinflammatory cytokines IL-1beta, TNF-alpha, and IL-6 in the etiology of chemotherapy-related anorexia, cachexia, anemia, pain, sleep disturbance, fatigue, and depression. CONCLUSIONS Further investigation into the role of these cytokines in the genesis of chemotherapy-related symptoms is warranted. The development of appropriate animal models likely will be key to understanding the relationship among cancer chemotherapy, proinflammatory cytokines, and symptoms. IMPLICATIONS FOR NURSING Nurses traditionally have been leaders in symptom management. The symptoms experienced by patients undergoing chemotherapy have a profound negative impact on quality of life and patients' ability to receive prescribed treatments. An understanding of potential mechanisms underlying the physiologic and behavioral consequences of chemotherapy administration will aid nurses in the development of interventions to effectively manage chemotherapy-related symptoms.